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Dietary Fatty Acids

Monounsaturated Fatty Acids Diet for Metabolic Syndrome

N/A

Waitlist Available

Led By Patrick Couture, MD, FRCP, PhD

Research Sponsored by Laval University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Men and women aged between 18-60 years

Be between 18 and 65 years old

Must not have

Subjects with a monogenic dyslipidemia

Men and women < 18 or > 60 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

No Placebo-Only Group

Summary

This trial will investigate how replacing dietary saturated fatty acids with monounsaturated fatty acids reduces cardiovascular risk in people with insulin-resistance and dyslipidemia.

Who is the study for?

This trial is for men and women aged 18-60 with metabolic syndrome, characterized by high triglycerides, large waist circumference, elevated fasting blood glucose, low HDL cholesterol levels, and normal blood pressure. It excludes those on certain medications or with conditions affecting the study's integrity.

What is being tested?

The trial tests how a diet rich in monounsaturated fatty acids (MUFAs) versus one high in saturated fatty acids (SFAs) affects intestinal lipid metabolism in insulin-resistant subjects to potentially reduce cardiovascular disease risk.

What are the potential side effects?

While not explicitly listed, potential side effects may include changes in digestion or nutrient absorption due to dietary adjustments. Individual responses can vary based on personal health and metabolism.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 60 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a genetic condition affecting my cholesterol levels.

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I am younger than 18 or older than 60.

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I have type 2 diabetes.

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I have a history of heart disease.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Saturated fatty acids dietExperimental Treatment2 Interventions

During 4 weeks, subjects eat a diet high in polyunsaturated fatty acids (percent of total caloric intake: 15.0% from proteins; 50.0% from carbohydrates; 35.0% from fat: 13.4% from saturated fat; 14.4% from monounsaturated fat; 7.2% from n-6 polyunsaturated fat).

Group II: Monounsaturated fatty acids dietExperimental Treatment2 Interventions

During 4 weeks, subjects eat a diet high in monounsaturated fatty acids (percent of total caloric intake: 15.0% from proteins; 50.0% from carbohydrates; 35.0% from fat: 7.1% from saturated fat; 20.7% from monounsaturated fat; 7.2% from n-6 polyunsaturated fat).

0 / 5Eligibility criteria met