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Behavioural Intervention
Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS
N/A
Waitlist Available
Led By Jessica E Huber, Ph.D.
Research Sponsored by Purdue University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured each week of training across the entire training duration
Awards & highlights
No Placebo-Only Group
Summary
This trial uses a device to help people with early stage ALS strengthen their breathing muscles. Participants will use the device at home for several weeks to improve their ability to communicate, cough, and breathe. The study is conducted entirely online with virtual sessions.
Eligible Conditions
- Amyotrophic Lateral Sclerosis
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline 2 (week 2), pre-training (week 3), post-training (week 10)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline 2 (week 2), pre-training (week 3), post-training (week 10)
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change From Baseline to Post-treatment for Maximum Expiratory Pressure
Secondary study objectives
ALS Function Rating Scale Revised
Adherence to Training Protocol
Change From Baseline to Post-Treatment in ALS Quality of Life Scale
+8 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Expiratory Muscle Strength TrainingExperimental Treatment1 Intervention
All participants will forcefully breathe out into an Expiratory Muscle Strength Training device (EMST-150) 25 times per day for 6 weeks. The EMST device will be set at a moderate intensity level (50% of each participant's maximum expiratory pressure).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Expiratory Muscle Strength Training (EMST-150)
2021
N/A
~20
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Who is running the clinical trial?
Purdue UniversityLead Sponsor
233 Previous Clinical Trials
71,360 Total Patients Enrolled
National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
354 Previous Clinical Trials
181,722 Total Patients Enrolled
7 Trials studying Amyotrophic Lateral Sclerosis
176 Patients Enrolled for Amyotrophic Lateral Sclerosis
Jessica E Huber, Ph.D.Principal InvestigatorPurdue University