Expiratory Muscle Strength Training (EMST-150) for Amyotrophic Lateral Sclerosis

N/A

Waitlist Available

Led By Jessica E Huber, Ph.D.

Research Sponsored by Purdue University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured each week of training across the entire training duration

Awards & highlights

No Placebo-Only Group

Summary

This trial uses a device to help people with early stage ALS strengthen their breathing muscles. Participants will use the device at home for several weeks to improve their ability to communicate, cough, and breathe. The study is conducted entirely online with virtual sessions.

Eligible Conditions

Amyotrophic Lateral Sclerosis

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline 2 (week 2), pre-training (week 3), post-training (week 10)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline 2 (week 2), pre-training (week 3), post-training (week 10)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline 2 (week 2), pre-training (week 3), post-training (week 10) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change From Baseline to Post-treatment for Maximum Expiratory Pressure

Secondary study objectives

ALS Function Rating Scale Revised

Adherence to Training Protocol

Change From Baseline to Post-Treatment in ALS Quality of Life Scale

+8 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Expiratory Muscle Strength TrainingExperimental Treatment1 Intervention

All participants will forcefully breathe out into an Expiratory Muscle Strength Training device (EMST-150) 25 times per day for 6 weeks. The EMST device will be set at a moderate intensity level (50% of each participant's maximum expiratory pressure).

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Expiratory Muscle Strength Training (EMST-150)

2021

N/A

~20

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