1665 Participants Needed

Blood Test for Multiple Myeloma

MD
Overseen ByMargarita Dzhanumova
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Wake Forest University Health Sciences
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to detect multiple myeloma, a type of blood cancer, at its early stage known as MGUS (monoclonal gammopathy of undetermined significance) to improve long-term health outcomes. It involves two groups: those with MGUS and smoldering multiple myeloma, and those with other plasma cell disorders. Individuals who identify as Black or African American, are 30 or older, and live in or near Charlotte, NC, might be a good fit. Participants should not have a history of certain plasma cell disorders.

As an unphased trial, this study offers a unique opportunity to contribute to early detection strategies and potentially improve future health outcomes for others.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Why are researchers excited about this trial?

Researchers are excited about the CHAAMP Internal Pilot Study because it aims to understand more about plasma cell disorders such as MGUS (monoclonal gammopathy of undetermined significance) and smoldering multiple myeloma, particularly in the African American population. Unlike treatments, this trial focuses on gathering data to improve early detection and risk stratification for these conditions. By identifying specific genetic or environmental factors affecting these disorders, the study could lead to more personalized approaches in the future. This could potentially fill the gap in knowledge about why African Americans might experience these conditions differently, ultimately leading to better-targeted interventions and outcomes.

Who Is on the Research Team?

MB

Manisha Bhutani, MD

Principal Investigator

Atrium Health Wake Forest Baptist Comprehensive Cancer Center

Are You a Good Fit for This Trial?

Inclusion Criteria

I identify as Black and/or African American.
I am 30 years old or older.
I am willing and able to give my consent for this trial.
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 year
Initial visit for blood draw

Diagnostic Evaluation

Participants screening positive for monoclonal gammopathy are referred for further diagnostic evaluation to confirm MGUS, SMM, or other PCD-related disorder

Approximately 90 days
Clinic referral for diagnostic workup

Longitudinal Follow-up

Participants diagnosed with MGUS and smoldering multiple myeloma are prospectively followed for 10 years

10 years
Regular follow-up visits as per protocol

What Are the Treatments Tested in This Trial?

Interventions

  • Blood draw

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Other Plasma Cell DisordersExperimental Treatment1 Intervention
Group II: MGUS and Smoldering Multiple MyelomaExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Wake Forest University Health Sciences

Lead Sponsor

Trials
1,432
Recruited
2,506,000+

Atrium Health Levine Cancer Institute

Collaborator

Trials
30
Recruited
4,700+