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Behavioural Intervention

Exercise Training for Multiple Sclerosis

N/A

Waitlist Available

Research Sponsored by University of Kansas Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subjects must be aged 40-65 years old to be enrolled in this study

Subjects must have an Expanded Disability Status Scale (EDSS) score ≤ 6.0

Must not have

Subjects with unstable cardiovascular conditions (e.g., malignant arrhythmias, critical mitral stenosis, clinically severe left ventricular outflow obstruction, critical proximal coronary artery stenosis)

Subjects diagnosed with other clinically important neurological conditions (such as Parkinson's Disease, epilepsy, etc.)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to study if exercise can help reduce frailty in people with Multiple Sclerosis. It will be the first research to look at targeting frailty in MS and will help understand how frailty

Who is the study for?

This trial is for people aged 40-65 with Multiple Sclerosis (MS) who are not currently having MS relapses, can function with some disability (EDSS score ≤ 6.0), speak English, and meet at least three out of five criteria indicating frailty such as weight loss, exhaustion, weakness, slowness in walking, or low physical activity.

What is being tested?

The study is testing whether a multimodal exercise program can reduce signs of frailty in those living with MS compared to a waitlist group. Participants will be randomly assigned to either start the exercise program immediately or placed on a waitlist as part of the control group.

What are the potential side effects?

Since this trial involves an exercise intervention rather than medication, side effects may include muscle soreness or fatigue due to increased physical activity. However specific side effects will depend on individual health conditions and responses to exercise.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 40 and 65 years old.

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I can walk at least 100 meters without aid or rest.

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My neurologist has confirmed I have multiple sclerosis.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I do not have severe heart problems like dangerous irregular heartbeats or major blockages in heart arteries.

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I have a significant neurological condition like Parkinson's or epilepsy.

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I cannot walk by myself for at least 10 meters.

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I am currently experiencing acute pain in my lower back or legs.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Multimodal Exercise GroupExperimental Treatment1 Intervention

Participants will complete 15 minutes of virtual reality treadmill training (VRTT), followed by 30 minutes of progressive evidence-based resistance training (RT), followed by other 15 minutes of VRTT.

Group II: Control GroupExperimental Treatment1 Intervention

Participants randomized to the control group will be put on a waitlist (passive control group) for 6 weeks. Upon completion of post-training assessment, participants in the control group will be able to receive the intervention, if they wish so.

0 / 7Eligibility criteria met