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Expiratory Muscle Strength Training (EMST) in Neuromuscular Disorders

N/A
Waitlist Available
Led By Gerald Pfeffer, MD, PhD
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in score from week 0 to week 5; change in score from week 0 to week 15; change in score from week 5 to week 15.

Summary

This trial looks at whether a muscle training programme can help people with OPMD to improve their swallowing, breathing, oral intake and quality of life, as well as their cough function.

Eligible Conditions
  • Acute Myeloid Leukemia
  • Oculopharyngeal Muscular Dystrophy
  • Muscular Dystrophy
  • Muscular dystrophy

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in score from week 0 to week 5; change in score from week 0 to week 15; change in score from week 5 to week 15.
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in score from week 0 to week 5; change in score from week 0 to week 15; change in score from week 5 to week 15. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Biomarker analyses
Forced vital capacity (FVC)
Global Swallowing Function
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: EMST therapyExperimental Treatment1 Intervention
Participants use the EMST device as per study protocol, set to 50% of the patient's maximal expiratory pressure, as measured by handheld manometer.
Group II: Sham EMST therapyPlacebo Group1 Intervention
Participants use a sham EMST device that has the spring removed as per study protocol, with no significant airflow resistance.

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
811 Previous Clinical Trials
892,795 Total Patients Enrolled
Muscular Dystrophy CanadaOTHER
3 Previous Clinical Trials
147 Total Patients Enrolled
Gerald Pfeffer, MD, PhDPrincipal InvestigatorUniversity of Calgary
~5 spots leftby Jan 2026
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