← Back to Search

Cardiac MRI Technique for Coronary Artery Disease (CATCH Trial)

N/A

Recruiting

Led By Debiao Li, PhD

Research Sponsored by Cedars-Sinai Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 1

Awards & highlights

No Placebo-Only Group

Summary

This trial will develop a new MRI technique, called CATCH, to more accurately and quickly assess coronary artery disease.

Who is the study for?

The CATCH trial is for adults over 18 with a BMI under 30, who are either healthy volunteers without cardiovascular disease or patients stable after coronary artery disease diagnosis and treatment. It excludes those with MR imaging contraindications like certain implants, claustrophobia, severe allergies to animal dander, poor kidney function (GFR <45ml/min), or past reactions to gadolinium contrast.

What is being tested?

CATCH aims to develop an MRI technique that enhances the evaluation of coronary atherosclerosis. The study will test this new method against traditional ones by comparing image quality and scanning efficiency. Participants may receive cardiac MRI scans using contrast agents and possibly beta blockers during the procedure.

What are the potential side effects?

Potential side effects include discomfort from lying still during the MRI scan, breath-holding difficulties, reactions to contrast agents such as mild allergic symptoms or nausea, and less commonly anxiety due to claustrophobia.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 1

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 1

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Plaque to Myocardial Ratio (PMR).

Secondary study objectives

Stenosis level (patient group only)

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Healthy VolunteersExperimental Treatment3 Interventions

Approximately 100 healthy male/female adult "normals" or "controls" will receive non-contrast or contrast-enhanced Cardiac MRI. Imaging may include administration of contrast and a beta blocker, based upon the focus of the study at the time of the scan, as well as the safety profile of the participant.

Group II: Coronary Artery Disease (CAD) PatientsExperimental Treatment3 Interventions

40 male/female adult outpatients who are suspected of having or have been diagnosed with coronary artery disease (CAD) will receive non-contrast or contrast-enhanced Cardiac MRI. Imaging may include administration of contrast and a beta blocker, based upon the focus of the study at the time of the scan, as well as the safety profile of the participant.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Cardiac MRI

2017

Completed Phase 4

~3210

Contrast

2011

Completed Phase 2

~160