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Radiation Therapy

Stereotactic Radiosurgery (SRS) for Brain Tumor

N/A
Waitlist Available
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months post radiosugery
Awards & highlights

Summary

The purpose of this study is to find out what effects, good and/or bad, stereotactic radiosurgery (Gamma knife) has on brain metastasis(es). Gamma knife radiosurgery is a way of giving radiation therapy to the brain in a very focused way, so that nearby parts of the brain receive very little exposure to radiation. No incisions are involved. Imaging technology is used to pinpoint the location of the tumor. In this study, the investigators are also trying to find out how the tumor and/or treatment affect brain function over time. The investigators will do this by performing a series of neurocognitive assessments, or tests of memory, reasoning, and higher brain function, before treatment and at regular intervals after treatment.

Eligible Conditions
  • Brain Tumor

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months post radiosugery
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months post radiosugery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Gamma knife radiosurgery treatment
Validation: To estimate consistency in change in z-scores for online oNCF and comprehensive clinical neurocognitive function (cNCF) neurocognitive assessments at baseline and 6-months in the office/clinic setting.
Secondary outcome measures
- Validation: To estimate consistency and change in scores for online neurocognitive (oNCF) and comprehensive clinical neurocognitive function (cNCF) assessments over all study time points.
-Feasibility: To demonstrate that at least 95% of participants will have no change from baseline and 12 months after treatment in their ability to complete the online neurocognitive function (oNCF) assessment.
Other outcome measures
Document the incidence of asymptomatic and symptomatic radiation necrosis in patients treated with gamma knife radiosurgery with or without whole brain radiation therapy WBRT (if WBRT is offered as salvage therapy)
To determine what healthcare cost data can be collected in patients with metastatic disease with the aim of estimating the relative healthcare cost of the Gamma Knife radiosurgery (prospective cost data collection).

Trial Design

1Treatment groups
Experimental Treatment
Group I: Stereotactic Radiosurgery (SRS)Experimental Treatment1 Intervention
Stereotactic radiosurgery technique via Gamma Knife® Perfexion™ radiosurgical system

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,551 Previous Clinical Trials
15,257,876 Total Patients Enrolled
North American Gamma Knife ConsortiumUNKNOWN
1 Previous Clinical Trials
Igor J Barani, MDStudy ChairUniversity of California, San Francisco
1 Previous Clinical Trials
~1 spots leftby Sep 2025
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