Advanced MRI-Guided Biopsy for Brain Cancer

N/A

Recruiting

Led By Dawid Schellingerhout, MD

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patient is a candidate for cerebral tumor resection with lesion suspected to be or previously biopsy proven to be a primary brain tumor

Be older than 18 years old

Must not have

The patient is found to have unfavorable anatomy to indicate that stereotactic biopsy could not be safely performed

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trialstudies if using advanced MRI helps guide needle biopsies of brain tumors, and if the results of the MRI and biopsies match. Up to 50 patients will take part at MD Anderson, with no costs to them.

Who is the study for?

This trial is for adults over 18 with suspected or confirmed primary brain tumors who need a tumor resection. They must understand and consent to the study, have an MRI before surgery, and have adequate kidney function. It's not for those with MR-unsafe implants/devices, prior brain tumor treatments (except biopsy), claustrophobia unmanageable by medication, or certain non-CNS malignancies.

What is being tested?

The study tests if advanced magnetic resonance imaging (AMRI) can better target needle biopsies of brain tumors than standard methods. Researchers will compare image results with biopsy findings to improve AMRI use in diagnosis. The perfusion scan used is investigational and only for research purposes.

What are the potential side effects?

Potential side effects may include discomfort from the MRI procedure, risks associated with additional anesthesia during surgery, reactions to special pathology stains or gene testing materials used in the study. However, no specific side effects are listed related to the AMRI itself.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am eligible for surgery to remove a brain tumor.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

My anatomy makes it unsafe to perform a stereotactic biopsy.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Comparison of the Accuracy of the Pathological Grades of Tumor Observed at the Biopsy Locations Identified Using Conventional Versus Advanced Imaging

Target Sample Grading

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Advanced MR Imaging (AMRI) ScanExperimental Treatment2 Interventions

AMRI scan performed within 2 weeks before standard of care brain surgery. During the surgery, neurosurgeon(s) use the information collected from the AMRI to decide what area of the brain tumor will be biopsied.

0 / 2Eligibility criteria met