Dietary Oils for Fatty Liver Disease

Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Ohio State University

Trial Summary

What is the purpose of this trial?The research study is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in hepatic lipid accumulation, visceral adipose tissue and postprandial lipid, markers of inflammation and energy metabolism in participants who consume 3 study foods per day for 16 week, while maintaining their body weight.

Eligibility Criteria

The WELL Study is for adults with Nonalcoholic Fatty Liver Disease (NAFLD) or similar conditions, who are nonsmokers with a BMI of 25-55 kg/m2. It's not for those with heart issues, pregnant or breastfeeding women, people unable to undergo venipuncture, those on certain diets or medications that conflict with the study foods, and individuals with specific gastrointestinal diseases, kidney failure, some liver and pulmonary diseases.

Inclusion Criteria

I have a liver condition not caused by alcohol.

Exclusion Criteria

I cannot have blood drawn because my veins are hard to access.

I am not on medications that restrict my diet.

I am currently being treated for a cancer that is not non-melanoma skin cancer.

My heart condition has been stable, with no events or surgeries in the last 3 months.

I don't have stomach or bowel problems that stop me from eating certain foods.

I have an overactive thyroid.

I do not have severe circulatory or autoimmune diseases.

I have been diagnosed with type 1 diabetes.

Treatment Details

This trial tests how daily consumption of foods made with soybean oil versus palm oil affects liver fat accumulation and other health markers over 16 weeks. Participants will be randomly assigned to one of these two dietary interventions while keeping their body weight stable.

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Soybean OilExperimental Treatment1 Intervention

Consumption of study foods each day made with soybean oil

Group II: Palm OilPlacebo Group1 Intervention

Consumption of study foods each day made with palm oil