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Behavioral Intervention

Exposure Therapy for OCD

N/A

Recruiting

Led By Jennie M Kuckertz, PhD

Research Sponsored by Mclean Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Between the ages of 18-65 years old

Have a diagnosis of OCD

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 12 weeks

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to understand why some patients with Obsessive Compulsive Disorder (OCD) do not fully recover with exposure therapy. The study will involve 400 adult participants receiving exposure therapy from two

Who is the study for?

This trial is for adults aged 18-65 with Obsessive Compulsive Disorder (OCD) who are seeking exposure therapy at McLean Hospital OCD Institute or San Diego State University. Participants must be able to complete study measures and treatment procedures in English.

What is being tested?

The study aims to identify key mechanisms that make exposure therapy effective for treating OCD by analyzing self-reported data, observer-rated behavior, and physiological responses like heart rate during therapy sessions.

What are the potential side effects?

Exposure therapy typically does not involve medication, so traditional side effects are minimal. However, it can temporarily increase anxiety levels as patients confront their fears.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 65 years old.

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I have been diagnosed with OCD.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Yale-Brown Obsessive Compulsive Scale (YBOCS)

Secondary study objectives

Quality of Life Enjoyment & Satisfaction Questionnaire (QLES)

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Exposure therapyExperimental Treatment1 Intervention

Participants will complete exposure therapy for up to 12 weeks, and each coached exposure session will be approximately 50 minutes. Exposure plans will be developed collaboratively between participants and their clinician at the beginning of treatment, and refined iteratively as clinically appropriate. In each coached exposure, participants will: 1. Complete an Exposure Feedback Form 2. Wear a wristwatch that provides psychophysiological data The intervention will occur across two study sites (McLean Hospital, San Diego State University). Sites will differ on level of care. At McLean Hospital, participants will be recruited from the OCD Institute and will receive exposure therapy via partial hospital or residential setting as part of their standard care, regardless of participation in the study. At San Diego State University, participants will be recruited to receive exposure therapy via outpatient setting.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Exposure therapy

2012

N/A

~190

0 / 2Eligibility criteria met