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Behavioural Intervention

High dose acupuncture for Osteoarthritis

N/A
Waitlist Available
Led By Jian Kong
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 days; one at baseline and another post-treatment measurement taken 5-7 weeks after baseline

Summary

In this proposal, we plan to dynamically investigate brain response to verum acupuncture (of two different "doses") and placebo acupuncture, using a paradigm that approximates clinical acupuncture practice across multiple treatment sessions in knee osteoarthritis (OA) patients. This proposal aims to: 1) characterize session-to-session brain responses to verum / sham acupuncture treatment (reliability of response) for OA patients, and 2) investigate how different "doses" of acupuncture influence brain response and acupuncture efficacy (impact of dose). The findings of this project will deepen our biological understanding on why and how acupuncture can treat chronic pain and what happens in the brain during the multiple-session acupuncture treatment.

Eligible Conditions
  • Osteoarthritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one post-treatment measurement 5-7 weeks after baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and one post-treatment measurement 5-7 weeks after baseline for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cortical Thickness Changes at 5-7 Weeks Post-Treatment
Knee Injury and Osteoarthritis Outcome Score (KOOS Pain Rating) at 5-7 Weeks Post-Treatment

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Low dose acupunctureExperimental Treatment1 Intervention
two needles will be applied.
Group II: High dose acupunctureExperimental Treatment1 Intervention
six needle applied during acupuncture
Group III: placebo acupuncturePlacebo Group1 Intervention
sham acupuncture treatment will be applied
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
acupuncture
2011
Completed Phase 3
~2640

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
3,020 Previous Clinical Trials
13,313,483 Total Patients Enrolled
20 Trials studying Osteoarthritis
4,844 Patients Enrolled for Osteoarthritis
National Center for Complementary and Integrative Health (NCCIH)NIH
860 Previous Clinical Trials
673,944 Total Patients Enrolled
23 Trials studying Osteoarthritis
5,790 Patients Enrolled for Osteoarthritis
Beth Israel Deaconess Medical CenterOTHER
855 Previous Clinical Trials
12,930,750 Total Patients Enrolled
2 Trials studying Osteoarthritis
249 Patients Enrolled for Osteoarthritis
~3 spots leftby Nov 2025
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