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Nonsteroidal Anti-Inflammatory Drug

Diclofenac for Osteoarthritis

N/A
Waitlist Available
Led By Michelle Dossett, MD, PhD
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* English-speaking
* 50 years of age or older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 minutes
Awards & highlights

Summary

The goal of this clinical trial is to understand the patient and clinic visit characteristics that affect health outcomes for individuals with knee osteoarthritis (OA) pain using topical diclofenac gel. The main questions it aims to answer are: * What baseline patient characteristics predict response to topical diclofenac? * Does patient physiology during the study visit predict response to topical diclofenac? * Do study visit characteristics predict response to topical diclofenac? Participants will: * attend 2 study visits to complete study questionnaires and have blood drawn * apply topical diclofenac to their knee for 8 weeks * complete biweekly questions about knee pain and diclofenac use between study visits

Who is the study for?
This trial is for individuals with knee osteoarthritis who are willing to apply diclofenac gel on their knee and can attend two study visits. Participants will also need to answer biweekly questions about their knee pain and treatment usage.
What is being tested?
The study aims to determine how patient characteristics, physiological responses during clinic visits, and the nature of these visits influence the effectiveness of topical diclofenac gel in managing knee OA pain.
What are the potential side effects?
Topical Diclofenac may cause skin irritation at the application site, stomach problems if absorbed into the bloodstream in significant amounts, liver issues, or an allergic reaction.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Knee Function
Knee Pain
Secondary study objectives
Change in patient RMSSD (root mean square of successive differences)
Change in patient skin conductance response
Global Impressions
+3 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: DiclofenacExperimental Treatment1 Intervention
All study participants receiving topical diclofenac.

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Who is running the clinical trial?

University of California, DavisLead Sponsor
921 Previous Clinical Trials
4,720,897 Total Patients Enrolled
2 Trials studying Osteoarthritis
99 Patients Enrolled for Osteoarthritis
Beth Israel Deaconess Medical CenterOTHER
841 Previous Clinical Trials
13,011,719 Total Patients Enrolled
2 Trials studying Osteoarthritis
73 Patients Enrolled for Osteoarthritis
National Institute on Aging (NIA)NIH
1,705 Previous Clinical Trials
28,033,257 Total Patients Enrolled
30 Trials studying Osteoarthritis
10,013 Patients Enrolled for Osteoarthritis
~147 spots leftby May 2027
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