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Procedure

Knee Replacement Surgeries for Osteoarthritis

N/A
Waitlist Available
Led By Kelly D Johnston, MD
Research Sponsored by Alberta Hip and Knee Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Angular deformity <15 degrees passively correctible to neutral
Flexion contracture <5 degrees
Must not have
Previous contralateral knee replacement surgery or major ligament reconstruction surgery
Severe patellofemoral joint OA
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights
No Placebo-Only Group

Summary

This trial is comparing two different types of knee surgery to see which one works better for people with no to moderate anteromedial knee osteoarthritis.

Who is the study for?
This trial is for people aged 40-80 with anteromedial knee osteoarthritis, a BMI under 40, and an intact ACL. They should have normal or mild to moderate patellofemoral joint OA and no severe deformities or previous major surgeries on the affected knee.
What is being tested?
The study compares two types of knee surgery: Total Knee Arthroplasty (TKA) using Zimmer Persona implants versus Unicompartmental Knee Arthroplasty (UKA) using Biomet Oxford implants. It measures outcomes like pain, function, and gait over two years.
What are the potential side effects?
Potential side effects include pain at the surgery site, swelling, infection risk, blood clots in the legs or lungs, stiffness in the knee joint after surgery, and possible need for revision surgery.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My joint can almost straighten out fully on its own.
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My joint bends almost fully, with less than 5 degrees of limitation.
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My knee arthritis is in a specific area and my ACL is not damaged.
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My knee pain is due to mild or moderate arthritis.
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I am between 40 and 80 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had surgery on the knee of my other leg.
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I have severe knee pain due to arthritis.
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I have had surgery on my knee before, but it was not a simple meniscus removal.
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I have a type of joint inflammation.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Gait analysis score

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Unicompartment knee arthroplasty/OxfordExperimental Treatment2 Interventions
Unicompartmental knee arthroplasty with Biomet Oxford mobile-bearing unicompartmental knee prosthesis (Biomet, Warsaw, IN)
Group II: Total knee arthroplasty/PersonaActive Control2 Interventions
Total knee arthroplasty with Zimmer Persona posterior cruciate retaining prosthesis (Zimmer, Warsaw, IN)

Find a Location

Who is running the clinical trial?

Alberta Hip and Knee ClinicLead Sponsor
3 Previous Clinical Trials
320 Total Patients Enrolled
2 Trials studying Osteoarthritis
220 Patients Enrolled for Osteoarthritis
Kelly D Johnston, MDPrincipal InvestigatorUniversity of Calgary Cumming School of Medicine

Media Library

Total knee arthroplasty (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT02430129 — N/A
Osteoarthritis Research Study Groups: Total knee arthroplasty/Persona, Unicompartment knee arthroplasty/Oxford
Osteoarthritis Clinical Trial 2023: Total knee arthroplasty Highlights & Side Effects. Trial Name: NCT02430129 — N/A
Total knee arthroplasty (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02430129 — N/A
~4 spots leftby Dec 2025
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