Dried Plums for Osteoporosis

Palo Alto (17 mi)

Overseen byMary Jane De Souza, PhD

Age: 18+

Sex: Female

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Penn State University

No Placebo Group

Trial Summary

What is the purpose of this trial?Postmenopausal women often seek non-pharmacologic interventions for the protection of bone health. Previous research in humans and rodents has indicated that dietary dried plum consumption may be beneficial for bone health, especially in postmenopausal women. However, it is unknown in what quantity dried plums need to be consumed to be of benefit and through what mechanisms dried plums act to impact bone health. Therefore, the purpose of this study is to evaluate the impact of 52 weeks of dried plums consumption in varying quantities on bone mineral density (BMD), bone geometry, and estimated bone strength in postmenopausal women. The investigators also seek to evaluate the mechanisms underlying the effects of dried plums as a dietary supplement by assessing polyphenols and the bioavailable conjugated metabolites in the urine of postmenopausal women taking different doses of dietary dried plums. The investigators aim to further investigate the mechanisms of dried plum action on bone by measuring markers of bone metabolism in response to dried plum consumption.

Eligibility Criteria

This trial is for postmenopausal women with low bone mineral density but not severe obesity or significant health issues like heart disease, kidney problems, or untreated thyroid conditions. Participants should be non-smokers, able to walk, and willing to eat dried plums daily without taking other natural dietary supplements.

Inclusion Criteria

I can walk on my own without help.

I am a woman who has gone through menopause.

My bone density test shows I have low bone mass.

Exclusion Criteria

I have a history of heart, blood clot, kidney issues, malabsorption, or seizures.

I have had a bone fracture after age 50.

My parathyroid gland is overactive or underactive.

I am HIV positive or have Hepatitis B/C and cancer.

I will not take any supplements not approved by the study.

My kidneys do not work well and I have high potassium levels.

I have been diagnosed with spinal stenosis.

I have untreated thyroid issues.

Treatment Details

The study tests the effects of eating different amounts of dried plums for a year on bone strength in postmenopausal women. It will measure changes in bone density and investigate how compounds from the plums might affect bone metabolism.

3Treatment groups

Experimental Treatment

Group I: Ca2+/VitD ControlExperimental Treatment2 Interventions

Participants will take calcium and vitamin D supplements for the duration of the baseline and intervention. Participants will be asked to refrain from consumption of dried plums for the duration of the intervention (52 weeks).

Group II: 50g Dried PlumsExperimental Treatment3 Interventions

Participants will take calcium and vitamin D supplements for the duration of the baseline and intervention. Additionally, participants will be provided with dried plums and asked to consume 6 (50g) dried plums per day for the duration of the intervention (52 weeks).

Group III: 100g Dried PlumsExperimental Treatment3 Interventions

Participants will take calcium and vitamin D supplements for the duration of the baseline and intervention. Additionally, participants will be provided with dried plums and asked to consume 12 (100g) dried plums per day for the duration of the intervention (52 weeks).