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Polyphenols

Olive Oil Polyphenols for Cardiovascular Health

N/A
Waitlist Available
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Must not have
Documented chronic diseases including diabetes, thyroid disease, kidney disease, metabolic syndrome, active cancer, previous cardiovascular events, history of gastric bypass or other GI issues related to fat absorption
Taking exogenous hormones (e.g. hormonal birth control)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 8 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial will study the effects of two types of olive oil on cardiovascular disease risk factors.

Who is the study for?
This trial is for generally healthy men and women aged 20-45 with a BMI of 18.5-29.9 or ≥30 for obese individuals. Exclusions include smokers, heavy alcohol users, drug users, those unable to consent, pregnant/lactating women, people with high cholesterol or blood sugar levels, olive allergies, extreme diets/exercise habits, certain chronic diseases or medication use.
What is being tested?
The study aims to see if consuming low-polyphenol versus high-polyphenol olive oil affects cardiovascular health markers like good/bad cholesterol levels, inflammation indicators and gene expression related to heart disease risk in healthy/overweight and obese participants.
What are the potential side effects?
While not explicitly stated in the provided information, potential side effects may include digestive discomfort due to changes in diet from introducing different types of olive oils.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a chronic condition like diabetes, thyroid, kidney disease, or a history of heart issues.
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I am currently taking hormonal medications, like birth control.
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I have difficulty with blood draws or IV access.
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I am an adult who can consent, not pregnant, not planning pregnancy soon, and not imprisoned.
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I am taking medications or supplements that affect cholesterol or use more than 1g of fish oil/day, antioxidants, or CBD oil.
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I have had high cholesterol or blood sugar levels.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 8 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Assessing the influence of olive oil polyphenols on blood lipid measurements
Assessing the influence of olive oil polyphenols on cholesterol efflux
Assessing the influence of olive oil polyphenols on cholesterol ester transfer protein activity (CETP)
+3 more
Secondary study objectives
Assessing the influence of olive oil polyphenols on gene expression in mirco RNA in PBMCs
Other study objectives
Anthropometric measurements
Assessing the influence of olive oil polyphenols on circulating cytokines
Assessing the influence of olive oil polyphenols on urine metabolites
+3 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: High-polyphenol olive oilActive Control1 Intervention
Participants will consume 40 mL of high-polyphenol olive oil each day at home for 2 weeks.
Group II: Low-polyphenol olive oilActive Control1 Intervention
Participants will consume 40 mL of low-polyphenol olive oil each day at home for 2 weeks.

Find a Location

Who is running the clinical trial?

University of California, DavisLead Sponsor
946 Previous Clinical Trials
4,756,086 Total Patients Enrolled
31 Trials studying Obesity
33,661 Patients Enrolled for Obesity

Media Library

High-polyphenol olive oil (Polyphenols) Clinical Trial Eligibility Overview. Trial Name: NCT04149288 — N/A
Obesity Research Study Groups: High-polyphenol olive oil, Low-polyphenol olive oil
Obesity Clinical Trial 2023: High-polyphenol olive oil Highlights & Side Effects. Trial Name: NCT04149288 — N/A
High-polyphenol olive oil (Polyphenols) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04149288 — N/A
~11 spots leftby Dec 2025
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