Olive Oil Polyphenols for Cardiovascular Health

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of California, Davis

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this research is to investigate whether consuming two different kinds of olive oil will change risk factors related to cardiovascular disease, including levels of good and bad cholesterol, levels of inflammation, and levels of gene expression.

Eligibility Criteria

This trial is for generally healthy men and women aged 20-45 with a BMI of 18.5-29.9 or ≥30 for obese individuals. Exclusions include smokers, heavy alcohol users, drug users, those unable to consent, pregnant/lactating women, people with high cholesterol or blood sugar levels, olive allergies, extreme diets/exercise habits, certain chronic diseases or medication use.

Inclusion Criteria

I am between 20-45 years old and my BMI is either in the healthy to overweight range or I am considered obese.

Exclusion Criteria

I have a chronic condition like diabetes, thyroid, kidney disease, or a history of heart issues.

My weight has changed by more than 10% in the last 6 months.

I am currently taking hormonal medications, like birth control.

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Participant Groups

The study aims to see if consuming low-polyphenol versus high-polyphenol olive oil affects cardiovascular health markers like good/bad cholesterol levels, inflammation indicators and gene expression related to heart disease risk in healthy/overweight and obese participants.

2Treatment groups

Active Control

Group I: High-polyphenol olive oilActive Control1 Intervention

Participants will consume 40 mL of high-polyphenol olive oil each day at home for 2 weeks.

Group II: Low-polyphenol olive oilActive Control1 Intervention

Participants will consume 40 mL of low-polyphenol olive oil each day at home for 2 weeks.