Trial Summary
What is the purpose of this trial?This is a blinded pilot study in which patients scheduled for pancreaticoduodenectomy for pancreatic or related cancers are randomized to dietary counseling and home exercise at high weekly frequency, either with or without individualized resistance training, in order to determine if such an intervention and research design are feasible in this population. We also aim to determine if physical function or quality of life can be improved with only 2-3 weeks of prehabilitation. This is in preparation for a larger study to determine if resistance improves outcomes.
Eligibility Criteria
This trial is for individuals over 30 with suspected pancreatic or related tumors who are fit to exercise and can understand English. They must be able to move without help, agree to random assignment in home-based exercise programs, and use protein supplements if needed. Those already on a substantial exercise or protein regimen may only join the observational part of the study.Inclusion Criteria
I can walk around my house without help.
I am older than 30 years.
Treatment Details
Participants will receive dietary counseling and engage in home exercises at high frequency before surgery for pancreatic cancer. The study tests two types of pre-surgery 'prehabilitation': standard vs enhanced (with resistance training) exercises, aiming to improve physical function and quality of life within 2-3 weeks.
2Treatment groups
Experimental Treatment
Group I: Standard Exercise GroupExperimental Treatment2 Interventions
Patients receive a single instruction session with a physical therapist, for training in moderate intensity (using Rate of Perceived Exertion) exercise including cardiovascular endurance, flexibility, and AROM of upper and lower body. If no other preferred mode of endurance training, a home ergometer is provided for use with arms and/or legs.
Group II: Enhanced Exercise GroupExperimental Treatment2 Interventions
Patients receive a single instruction session with a physical therapist, for training in moderate intensity (using Rate of Perceived Exertion) exercise including cardiovascular endurance, flexibility, and resistance exercise for upper and lower body. If no other preferred mode of endurance training, a home ergometer is provided for use with arms and/or legs.
Find a clinic near you
Research locations nearbySelect from list below to view details:
University of Oklahoma Health Sciences CenterOklahoma City, OK
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Who is running the clinical trial?
University of OklahomaLead Sponsor