Irreversible Electroporation for Pancreatic Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to better understand how Irreversible Electroporation (IRE) can assist people with pancreatic cancer when surgery isn't an option. Researchers seek to determine the optimal timing and application of this treatment, as well as potential challenges or side effects. Suitable candidates for this trial have pancreatic cancer and receive a recommendation from their doctor for soft tissue ablation, which targets the cancer without traditional surgery. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to significant advancements in cancer care.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that pancreatic irreversible electroporation (IRE) is safe for treating pancreatic cancer?
Research has shown that pancreatic irreversible electroporation (IRE) can cause moderate side effects. One study found that about 25% of patients experienced adverse reactions, such as post-procedure pain and pancreatitis, which is inflammation of the pancreas. However, since IRE does not use heat or cold, it is less likely to damage nearby healthy tissues compared to other treatments.
Another study indicated that IRE can be safely combined with standard chemotherapy for treating pancreatic cancer. While some risks exist, many patients tolerate the treatment well when used alongside other cancer therapies.12345Why are researchers excited about this trial?
Researchers are excited about Pancreatic Irreversible Electroporation (IRE) because it offers a unique approach to treating pancreatic cancer. Unlike traditional treatments such as surgery, chemotherapy, or radiation, IRE uses electrical pulses to target and destroy cancer cells without damaging surrounding healthy tissue. This precision could mean fewer side effects and potentially better outcomes for patients. Additionally, IRE may be an option for tumors that are considered inoperable, providing hope for patients with limited treatment options.
What evidence suggests that pancreatic IRE is effective for pancreatic cancer?
Research has shown that Pancreatic Irreversible Electroporation (IRE) is a promising treatment for pancreatic cancer, particularly for tumors that cannot be surgically removed. Studies have found that IRE uses electrical pulses to effectively target and destroy cancer cells, helping to shrink or eliminate tumors with clear edges. For patients with locally advanced pancreatic cancer, IRE has improved survival rates, offering an important option when traditional surgeries are not possible. Additionally, IRE is well-tolerated and does not use heat, making it a safer choice for treating tumors near sensitive areas. This evidence supports the potential of IRE as a valuable tool in treating challenging pancreatic cancers.678910
Who Is on the Research Team?
Robert Martin, MD, PhD
Principal Investigator
University of Louisville
Are You a Good Fit for This Trial?
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo pancreatic irreversible electroporation (IRE) treatment for unresectable soft tissue pancreatic tumors
Follow-up
Participants are monitored for safety, effectiveness, and adverse events after treatment
Long-term follow-up
Capture overall survival and long-term adverse events in patients treated with IRE
What Are the Treatments Tested in This Trial?
Interventions
- Pancreatic Irreversible Electroporation (IRE)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Louisville
Lead Sponsor
The Americas Hepato-Pancreato-Biliary Association
Collaborator