Monoclonal Gammopathy for Unique Populations

(MAGIC Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Mayo Clinic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine the prevalence of monoclonal gammopathy in individuals of East African descent. Monoclonal gammopathy involves abnormal proteins in the blood and can sometimes progress to more serious conditions like multiple myeloma. Researchers seek to better understand how this condition affects the East African community to improve treatment and prevention strategies. Individuals with East African ancestry who are 40 years or older may be suitable for this study. Participants will have their medical history reviewed, provide a blood sample, and complete a questionnaire.

As an unphased study, this trial offers participants the chance to contribute to significant research that could enhance health outcomes for their community.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Why are researchers excited about this trial?

Researchers are excited about this trial because it aims to understand the prevalence of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Multiple Myeloma (MM) specifically among unique populations of Black people. Unlike standard treatment options that focus on managing these conditions, this trial is observational and seeks to identify how often MGUS and MM occur, potentially leading to earlier detection and better-targeted treatments in the future. By focusing on medical chart reviews and blood sample analysis, this study could reveal critical insights into racial disparities in these diseases, ultimately contributing to more personalized and effective healthcare solutions.

Who Is on the Research Team?

JM

Joselle M. Cook, M.B.B.S.

Principal Investigator

Mayo Clinic in Rochester

Are You a Good Fit for This Trial?

Inclusion Criteria

I am of East African descent.
I am willing and able to give consent for study procedures.
I am 40 years old or older.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Observational

Participants undergo medical chart review, blood sample collection, and complete a questionnaire. Those who test positive for MGUS are notified along with their primary care physician.

Ongoing

Follow-up

Participants who test positive for MGUS receive necessary follow-up and referral as clinically indicated.

Up to 10 years

What Are the Treatments Tested in This Trial?

Interventions

  • Non-Interventional Study

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: ObservationalExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+