Brain Stimulation + Physical Therapy for Parkinson's Disease
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: Spaulding Rehabilitation Hospital
No Placebo Group
Trial Summary
What is the purpose of this trial?This trial aims to understand the mechanism and to test whether transcranial direct current stimulation (tDCS) combined with transcranial ultrasound (TUS) (tDCS+TUS) combined with physical therapy (PT) will induce significant therapeutic effects in postural instability in Parkinson's disease (PT) patients. The investigators designed a double-blinded, placebo controlled, randomized study to investigate the effects of 2 weeks of TDCS+TUS on postural instability in PD patients receiving PT. (Followed by biweekly sessions for 2 more weeks in Phase II)
Eligibility Criteria
This trial is for people aged 40-90 with Parkinson's Disease who have balance issues or postural instability and are on stable PD medications. Excluded are those with other balance-affecting conditions, brain surgeries, metal in the head, severe medical problems, pregnancy, recent PT programs, non-PD parkinsonism syndromes, certain psychiatric or substance abuse histories.Inclusion Criteria
I am between 40 and 90 years old.
Exclusion Criteria
I have had brain surgery or have malignant brain tumors.
My medical conditions, like diabetes or heart issues, are under control.
I have a condition like epilepsy or another that makes seizures more likely.
I am confined to a bed or wheelchair.
Participant Groups
The study tests if brain stimulation (tDCS) plus ultrasound (TUS), along with physical therapy (PT), can improve stability in Parkinson's patients. It's a double-blind study where participants randomly get either real treatment or sham (fake) versions for two weeks followed by biweekly sessions.
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active tDCS and Active TUSExperimental Treatment2 Interventions
Active tDCS and Active TUS for 20 min
Group II: Sham TDCS and Sham TUSPlacebo Group2 Interventions
Sham TDCS and Sham TUS for 20 min
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
Spaulding Rehabilitation Network Research InstituteCharlestown, MA
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Who is running the clinical trial?
Spaulding Rehabilitation HospitalLead Sponsor
Highland Instruments, Inc.Industry Sponsor