Parkinson's Disease > Active TDCS And Active TUS

Brain Stimulation + Physical Therapy for Parkinson's Disease

Recruiting in Palo Alto (17 mi)

Overseen By Felipe Fregni, MD, PhD, MPH

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Spaulding Rehabilitation Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial aims to understand the mechanism and to test whether transcranial direct current stimulation (tDCS) combined with transcranial ultrasound (TUS) (tDCS+TUS) combined with physical therapy (PT) will induce significant therapeutic effects in postural instability in Parkinson's disease (PT) patients. The investigators designed a double-blinded, placebo controlled, randomized study to investigate the effects of 2 weeks of TDCS+TUS on postural instability in PD patients receiving PT. (Followed by biweekly sessions for 2 more weeks in Phase II)

Eligibility Criteria

This trial is for people aged 40-90 with Parkinson's Disease who have balance issues or postural instability and are on stable PD medications. Excluded are those with other balance-affecting conditions, brain surgeries, metal in the head, severe medical problems, pregnancy, recent PT programs, non-PD parkinsonism syndromes, certain psychiatric or substance abuse histories.

Inclusion Criteria

I am between 40 and 90 years old.

Exclusion Criteria

I have had brain surgery or have malignant brain tumors.

My medical conditions, like diabetes or heart issues, are under control.

I have a condition like epilepsy or another that makes seizures more likely.

I am confined to a bed or wheelchair.

Participant Groups

The study tests if brain stimulation (tDCS) plus ultrasound (TUS), along with physical therapy (PT), can improve stability in Parkinson's patients. It's a double-blind study where participants randomly get either real treatment or sham (fake) versions for two weeks followed by biweekly sessions.

Group I: Active tDCS and Active TUS Experimental Treatment 2 Interventions

Active tDCS and Active TUS for 20 min

Group II: Sham TDCS and Sham TUS Placebo Group 2 Interventions

Sham TDCS and Sham TUS for 20 min

Find A Clinic Near You

Research locations nearby Select from list below to view details:

Spaulding Rehabilitation Network Research Institute Charlestown, MA

Who is running the clinical trial?

Spaulding Rehabilitation Hospital Lead Sponsor

Highland Instruments, Inc. Industry Sponsor

References