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Exercise for Parkinson's Disease (EBEPD Trial)
N/A
Recruiting
Led By Vesna Sossi
Research Sponsored by Pacific Parkinson's Research Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up six months
Summary
This trialundefined
Who is the study for?
This trial is for people with Parkinson's Disease who can lay still for up to 90 minutes and are medically cleared to exercise. They shouldn't have severe claustrophobia, metal implants, significant cardiovascular or respiratory disease, other neurological or psychiatric disorders, recent surgeries or tattoos, substance use problems, be pregnant/breastfeeding, weigh over 158kg (347 lbs), or have a history of cancer within the last 5 years.
What is being tested?
The study investigates if active and passive exercises affect brain energy usage in Parkinson's patients by comparing before-and-after brain scans using fMRI and PET. Healthy volunteers will also be scanned for comparison. Participants must currently exercise less than two hours per week.
What are the potential side effects?
While not drug-related, side effects may include typical risks associated with physical exercise such as muscle soreness or strain. The imaging procedures might cause discomfort due to lying still in a confined space during scanning.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ six months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~six months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
PET/MRI
Other study objectives
Clinical measure: cognitive function
Clinical measure: motor function
Trial Design
2Treatment groups
Active Control
Placebo Group
Group I: Immediate intervention start: active exerciseActive Control1 Intervention
Immediately starts the six month intervention of active exercise following the baseline scan.
Group II: Delayed intervention start: passive exercisePlacebo Group2 Interventions
Starts the six month intervention of active exercise six months after the baseline scan. During the six month delay, participants in this arm undergo passive exercise.
Find a Location
Who is running the clinical trial?
Pacific Parkinson's Research CentreLead Sponsor
6 Previous Clinical Trials
125 Total Patients Enrolled
Natural Sciences and Engineering Research Council, CanadaOTHER
62 Previous Clinical Trials
3,242 Total Patients Enrolled
Vesna SossiPrincipal InvestigatorUniversity of British Columbia