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Exercise for Parkinson's Disease (EBEPD Trial)

N/A

Recruiting

Led By Vesna Sossi

Research Sponsored by Pacific Parkinson's Research Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up six months

Summary

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Who is the study for?

This trial is for people with Parkinson's Disease who can lay still for up to 90 minutes and are medically cleared to exercise. They shouldn't have severe claustrophobia, metal implants, significant cardiovascular or respiratory disease, other neurological or psychiatric disorders, recent surgeries or tattoos, substance use problems, be pregnant/breastfeeding, weigh over 158kg (347 lbs), or have a history of cancer within the last 5 years.

What is being tested?

The study investigates if active and passive exercises affect brain energy usage in Parkinson's patients by comparing before-and-after brain scans using fMRI and PET. Healthy volunteers will also be scanned for comparison. Participants must currently exercise less than two hours per week.

What are the potential side effects?

While not drug-related, side effects may include typical risks associated with physical exercise such as muscle soreness or strain. The imaging procedures might cause discomfort due to lying still in a confined space during scanning.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ six months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~six months

This trial's timeline: 3 weeks for screening, Varies for treatment, and six months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

PET/MRI

Other study objectives

Clinical measure: cognitive function

Clinical measure: motor function

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Immediate intervention start: active exerciseActive Control1 Intervention

Immediately starts the six month intervention of active exercise following the baseline scan.

Group II: Delayed intervention start: passive exercisePlacebo Group2 Interventions

Starts the six month intervention of active exercise six months after the baseline scan. During the six month delay, participants in this arm undergo passive exercise.

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