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Movement Task Facilitation for Parkinson's Disease

N/A
Recruiting
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of idiopathic Parkinson's disease based on presence of at least 2 cardinal PD features (tremor, rigidity, or bradykinesia)
Be older than 18 years old
Must not have
Medical contraindication to surgery, including recent use of anticoagulant or antiplatelet therapy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights
No Placebo-Only Group

Summary

This trial will help researchers understand how different types of cues can help patients with Parkinson's disease move more normally, which may lead to new treatments.

Who is the study for?
This trial is for people with advanced Parkinson's disease who are already scheduled for deep brain stimulation surgery. They should be able to cooperate during an awake procedure and have symptoms that improve with L-dopa or have a medication-refractory disabling tremor. Participants must not have cognitive impairments, psychiatric diseases, or medical conditions that rule out surgery.
What is being tested?
The study aims to understand how certain stimuli facilitate movement in Parkinson's patients by recording brain activity during DBS surgery. Patients will perform movement tasks while awake, which could help identify new targets for treating symptoms unresponsive to current therapies.
What are the potential side effects?
Since the study involves standard clinical procedures of DBS surgery and no additional drugs, side effects are primarily related to the surgical process itself such as discomfort from being awake during the operation and potential risks associated with any surgical intervention.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have Parkinson's with symptoms like tremor, stiffness, or slow movement.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I cannot undergo surgery due to medical reasons, including recent use of blood thinners.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Frontal and parietal electrocorticography
Globus pallidus internus local field potentials

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Parkinson disease patientsExperimental Treatment1 Intervention
Parkinson disease patients undergoing DBS Surgery of the Globus Pallidus Internus (GPi) for clinical indications

Find a Location

Who is running the clinical trial?

National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,377 Previous Clinical Trials
651,797 Total Patients Enrolled
University of California, Los AngelesLead Sponsor
1,564 Previous Clinical Trials
10,262,593 Total Patients Enrolled

Media Library

Movement task Clinical Trial Eligibility Overview. Trial Name: NCT05166655 — N/A
Parkinson's Disease Research Study Groups: Parkinson disease patients
Parkinson's Disease Clinical Trial 2023: Movement task Highlights & Side Effects. Trial Name: NCT05166655 — N/A
Movement task 2023 Treatment Timeline for Medical Study. Trial Name: NCT05166655 — N/A
~16 spots leftby Sep 2026
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