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Neurologic Music Therapy for Parkinson's Disease

N/A

Recruiting

Led By Isabelle Buard, PhD

Research Sponsored by University of Colorado, Denver

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Fine motor impairments (if available, scores 2 and higher on the UPDRS motor examination part III.23 and 24)

Age 45 to 85

Must not have

Inability to move fingers or hands

Features suggestive of other causes of parkinsonism, including cerebrovascular disease or history of major head trauma

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and 5 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial will test whether Neurologic Music Therapy can help improve fine motor movements for adults with Parkinson's Disease.

Who is the study for?

Adults aged 45-85 with Parkinson's Disease, experiencing fine motor impairments, and stable on medication for at least a month can join. Excluded are those with other forms of parkinsonism, inability to move fingers or hands, involvement in other music therapy studies, lack of insurance coverage for Occupational Therapy, advanced Parkinson's (stage 4+), metal implants affecting MEG/MRI data or safety concerns, and dementia.

What is being tested?

The trial is testing Neurologic Music Therapy (NMT) against Music Supported Therapy (MST) and standard Occupational Therapy (OT). It aims to see if NMT improves fine motor skills in Parkinson’s patients by using musical instruments and rhythm exercises compared to MST and OT.

What are the potential side effects?

Since the interventions involve music therapy and occupational activities rather than drugs or invasive procedures, significant side effects are not anticipated. However, participants may experience fatigue or frustration during the sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have difficulty with tasks that require small, precise movements.

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I am between 45 and 85 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I cannot move my fingers or hands.

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My Parkinson's symptoms are not due to a stroke or major head injury.

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My Parkinson's disease is in an advanced stage.

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My insurance does not cover Occupational Therapy, or I am uninsured.

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I have been diagnosed with dementia.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and 5 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and 5 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 5 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Clinical Outcome: Motor 1 (change in the Grooved Pegboard Test)

Magnetoencephalography

Mechanistic Outcome: Neurophysiology 2 (change in auditory-motor functional connectivity using Magnetoencephalography)

+1 more

Secondary study objectives

Clinical Outcome: Motor 2 (change in the Unified Parkinson Disease Rating Scale Part III)

Clinical Outcome: Motor 3 (change in the Finger-Thumb opposition from the Neurological Evaluation Scale)

Quality of Life (QOL) Outcome: QOL 2 (change in the Clinical Global Impression - Improvement Scale)

+1 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups

Experimental Treatment

Active Control

Group I: Neurologic Music Therapy (NMT)Experimental Treatment1 Intervention

Neurologic Music Therapy is a 5-week intervention using different musical instruments and auditory cues to specifically improve fine motor movements.

Group II: Occupational Therapy (OT)Active Control1 Intervention

Standard of care occupational therapy uses traditional motor training.

Group III: Waitlist ControlActive Control1 Intervention

Participants assigned to the waitlist-control condition will not immediately receive services. The no-treatment duration for these participants is yoked to the amount of time their respective NMT- and OT-condition participants receive services (5 weeks). After the wait period, these participants will then be randomized to receive either NMT, MST or OT sessions.

Group IV: Music Supported Therapy (MST)Active Control1 Intervention

Music Supported Therapy uses musical instruments to train fine motor movements.

0 / 7Eligibility criteria met