Action Regulation Movement Task for Parkinson's Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how medication affecting dopamine can improve movement control and decision-making in people with Parkinson's disease. Dopamine helps nerve cells communicate. The study will assess patients' ability to stop or switch actions and how treatment might alter this using the Action Regulation Movement Task. Participants with Parkinson's who already take medication like levodopa and notice improvements might be suitable candidates. The trial will also include healthy individuals without neurological issues for comparison. As an unphased trial, it offers participants the opportunity to contribute to valuable research that could enhance future treatment strategies.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, since the study involves patients already on dopaminergic medication, it seems likely you can continue your current treatment.
What prior data suggests that the Action Regulation Movement Task is safe for Parkinson's Disease patients?
Research shows that treatments affecting dopamine, like the one in this trial, are generally well-tolerated by people with Parkinson's disease. These treatments aid in the release of dopamine, a brain chemical that sends signals to nerve cells. Many patients taking these medications experience side effects such as nausea or dizziness, but these are usually mild and manageable.
While no specific safety studies exist for the "Action Regulation Movement Task," it focuses on improving movement and decision-making through exercises, not new drugs, suggesting it is likely safe.
In summary, previous research considers the treatments used in this study safe for most people with Parkinson's. Always consult a healthcare provider for personalized advice.12345Why are researchers excited about this trial?
Researchers are excited about the Action Regulation Movement Task for Parkinson's Disease because it introduces a non-drug approach to managing symptoms. Unlike standard treatments that often focus on medication like levodopa to manage dopamine levels, this behavioral task aims to enhance motor control and cognitive engagement without medication. It could offer a complementary way to improve quality of life for patients by potentially reducing reliance on drugs and their side effects. This innovative method could pave the way for more holistic treatment plans for Parkinson's disease.
What evidence suggests that the Action Regulation Movement Task is effective for Parkinson's disease?
Research has shown that action observation therapy, which involves watching and mentally practicing movements, can help people with Parkinson’s disease (PD). Studies have found that this type of training improves both movement skills and daily activities for those with PD. Watching and imagining movements can activate brain areas involved in movement, potentially leading to better control. Evidence also indicates that performing two tasks simultaneously, known as dual-task training, can enhance walking and balance in people with PD. These findings suggest that practicing these activities may improve movement and possibly reduce symptoms in people with PD. Participants in this trial will engage in the Action Regulation Movement Task to further explore these potential benefits.678910
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants complete baseline assessments including the Stop-Signal Task and Switch Task
Treatment
Participants receive dopaminergic treatment and complete behavioral tasks to assess action regulation
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Action Regulation Movement Task
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Patients that have been diagnosed with Parkinson's Disease and are responsive to levodopa medication. Patients will complete a behavioral task.
Men and women between the ages of 18-80. Spouse of PD patient who participates in this study with no history of any diagnosed neurological disease(s), including movement disorders or cognitive decline. No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Texas Southwestern Medical Center
Lead Sponsor
University of California, Riverside
Collaborator
Citations
The Effects of Action Observation Therapy as a ...
The results of the included studies generally suggest that AO training is effective in PD patients, both in motor and functional-related measures and self- ...
2.
frontiersin.org
frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1496112/fullEffects of different exercises on improving gait performance ...
Our study found that DE improved gait speed and step length in patients with Parkinson's disease better than other forms of exercise.
Action observation and motor imagery for rehabilitation in ...
This article discusses recent evidence supporting the use of action observation therapy and motor imagery practice for rehabilitation of Parkinson's disease.
4.
movementdisorders.onlinelibrary.wiley.com
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mdc3.13823Efficacy of Dual‐Task Training in Patients with Parkinson's ...
The main findings of our meta-analysis show that DTT is effective in improving the patient's gait, balance and motor impairments immediately ...
Effects of movement congruence on motor resonance in ...
This study demonstrates the preservation of MR mechanisms in early PD patients. The action observation finalized to a consequent movement can activate cortical ...
Action Regulation Behavioral | Clinical Research Trial ...
For Parkinson's Disease Patients: Inclusion Criteria: Diagnosis of Parkinson's Disease by a movement disorder neurologist; Levodopa ...
Patient-Specific 3D Action Observation Training in ...
The aim of the present study is to examine the effects of action observation training, delivered in a fully immersive virtual reality ...
Reaching and Grasping Movements in Parkinson's Disease
In this review, we summarize the literature results on reaching and grasping in parkinsonian patients. We analyze the relevant hypotheses on the origins of ...
Goal-directed behavior in individuals with mild Parkinson's ...
Self-efficacy and self-regulation skills are critical for goal-directed behavior. These skills and their neural bases were tested in mild Parkinson's disease.
NCT05184608 | Cycling Dual-task in Parkinson's Disease
A phase of research to describe clinical trials that focus on the safety of a drug. They are usually conducted with healthy volunteers, and the goal is to ...
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