Your session is about to expire
← Back to Search
Deep Brain Stimulation
Burst-Type Deep Brain Stimulation for Parkinson's Disease (BURST Trial)
N/A
Recruiting
Research Sponsored by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights
No Placebo-Only Group
Summary
This trial evaluates a new type of brain stimulation to improve effectiveness & durability of brain stimulation treatments.
Who is the study for?
This trial is for Parkinson's Disease patients who've had bilateral DBS-STN implants for at least 6 months, can use a DBS controller, and have stable medication and DBS settings. It excludes those with non-Boston scientific Genus/Gevia DBS tech, cognitive decline, or inability to complete follow-ups.
What is being tested?
The study compares burst-type DBS electrical stimulation programming—a new protocol delivering intermittent bursts of stimulation—with the standard continuous high-frequency stimulation in managing Parkinson's symptoms.
What are the potential side effects?
Potential side effects may include discomfort at the implant site, headache, temporary worsening of Parkinson's symptoms during adjustment periods, and rare risks associated with brain surgery like infection or bleeding.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in Unified Parkinson's Disease Rating Scale (UPDRS) v-III Motor Examination Score
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Experimental/Burst-type programmingExperimental Treatment1 Intervention
Burst-type DBS electrical stimulation
Group II: Standard of care programmingActive Control1 Intervention
Standard of care DBS electrical stimulation
Find a Location
Who is running the clinical trial?
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)Lead Sponsor
50 Previous Clinical Trials
12,977 Total Patients Enrolled
Boston Scientific CorporationIndustry Sponsor
746 Previous Clinical Trials
858,000 Total Patients Enrolled
1 Trials studying Dementia
2 Patients Enrolled for Dementia
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I cannot attend all the follow-up visits.My DBS targets in the brain are not the STN.I have had DBS for Parkinson's in both sides of my brain for at least 6 months.My Parkinson's medication and DBS settings have been stable for 6 months.I am experiencing worsening memory or thinking problems.
Research Study Groups:
This trial has the following groups:- Group 1: Standard of care programming
- Group 2: Experimental/Burst-type programming
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.