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Efficacy of Adjunctive Antimicrobial Photodynamic Therapy for Residual Pockets in Previously Surgically Treated Teeth

N/A
Waitlist Available
Research Sponsored by University of Manitoba
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up initial, 3 months, 6 months, 12 months.

Summary

Traditionally, periodontal gum surgery has been used as a method to gain access to inflamed periodontal pockets around teeth. The outcome of these surgeries, however, is not always successful as there can be recurrence of inflammation and disease. The objective of this study is to assess the effectiveness of antimicrobial photodynamic therapy as an adjunct to mechanical debridement of residual periodontal pockets in patients having undergone periodontal surgery. Pocket probing depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI) will be evaluated at all sites as measures of inflammation and disease resolution.

Eligible Conditions
  • Periodontitis
  • Gum Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~initial, 3 months, 6 months, 12 months.
This trial's timeline: 3 weeks for screening, Varies for treatment, and initial, 3 months, 6 months, 12 months. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in bleeding on probing (BOP)
Secondary study objectives
Change in pocket probing depth (PPD)
Change of clinical attachment level (CAL)
Change of plaque index (PI)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment GroupExperimental Treatment1 Intervention
Antimicrobial photodynamic therapy with methylene blue applied to test site after mechanical debridement.
Group II: Placebo GroupPlacebo Group1 Intervention
Photodynamic therapy laser is not activated with saline water in the test site after mechanical debridement.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Antimicrobial photodynamic therapy
2014
N/A
~60

Find a Location

Who is running the clinical trial?

University of ManitobaLead Sponsor
621 Previous Clinical Trials
206,539 Total Patients Enrolled
Anastasia Cholakis, M DentStudy DirectorUniversity of Manitoba
~3 spots leftby Jan 2026
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