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Cannabinoid

Cannabis Discontinuation for Sleep and Circadian Rhythm (CASCILS Trial)

Pittsburgh, PA

N/A

Recruiting

Led By Brant P Hasler, PhD

Research Sponsored by University of Pittsburgh

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18-25 years

Be between 18 and 65 years old

Must not have

Eye/retinal conditions such as diabetic retinopathy or glaucoma

Seizure disorder

Timeline

Screening 3 weeks

Treatment Varies

Follow Up discontinuation, 4 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to understand how using and stopping cannabis affects sleep, body clock, and sensitivity to light. It wants to find out if cannabis affects the need for sleep and how it impacts how our bodies

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Who is the study for?

This trial is for young adults who regularly use cannabis and may experience issues with sleep, their body's internal clock (circadian rhythm), or sensitivity to light. Participants should be interested in stopping cannabis use temporarily for the study.Check my eligibility

What is being tested?

The study is looking at how not using cannabis might change a person's sleep patterns, natural daily rhythms, and reaction to light. It will check if quitting affects how sleepy they feel or alters their sensitivity to light over time.See study design

What are the potential side effects?

Since this trial involves discontinuing cannabis, side effects could include withdrawal symptoms such as irritability, mood changes, sleep difficulties, decreased appetite, restlessness, and physical discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 25 years old.

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Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have an eye condition like diabetic retinopathy or glaucoma.

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I have a seizure disorder.

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I am not taking any benzodiazepines or 'Z-drugs'.

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I have a sleep disorder that is not insomnia or delayed sleep phase disorder.

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Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ discontinuation, 4 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~discontinuation, 4 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and discontinuation, 4 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Circadian Photosensitivity

Homeostatic Sleep Drive

Retinal Responsivity

Secondary study objectives

Circadian phase

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cannabis-UsingExperimental Treatment1 Intervention

The cannabis-using arm will consist of 60 young people reporting regular cannabis use. They will participate in a 1-week baseline protocol followed by a 4-week cannabis discontinuation protocol (intervention).

Group II: ControlActive Control1 Intervention

The control arm will consist of 30 young people without current cannabis use. They will participate in a 1-week baseline protocol. No intervention will be administered.

0 / 5Eligibility criteria met