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Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling (CRND TorCA Trial)

North York, Canada
N/A
Recruiting
Led By Maria C Tartaglia, M.D.
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6-month follow-up, 1-year follow-up
Awards & highlights
No Placebo-Only Group

Summary

To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).

See full description
Eligible Conditions
  • Parkinson's Disease
  • Alzheimer's Disease
  • Dementia
  • Frontotemporal Dementia
  • Lewy Body Dementia
  • Vascular Dementia
  • Mild Cognitive Impairment
  • Cortical Basal Ganglionic Degeneration
  • Progressive Supranuclear Palsy
  • Primary Progressive Aphasia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6-month follow-up, 1-year follow-up
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 6-month follow-up, 1-year follow-up for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cognitive phenotype
Secondary study objectives
Assessment of DNA methylation (DNAm) from bloodwork
Neurodegenerative protein levels in biofluids and skin biopsy
Structural and Functional Differences between neurodegenerative diseases via MRI of the brain

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Find a Location

Closest Location:Sunnybrook Health Sciences Centre· Toronto, Canada· 318 miles

Who is running the clinical trial?

BaycrestOTHER
45 Previous Clinical Trials
6,371 Total Patients Enrolled
Sunnybrook Health Sciences CentreOTHER
692 Previous Clinical Trials
1,568,431 Total Patients Enrolled
Centre for Addiction and Mental HealthOTHER
386 Previous Clinical Trials
83,720 Total Patients Enrolled
University of TorontoOTHER
735 Previous Clinical Trials
1,117,258 Total Patients Enrolled
University Health Network, TorontoLead Sponsor
1,549 Previous Clinical Trials
509,814 Total Patients Enrolled
Toronto Dementia Research Alliance (TDRA)UNKNOWN
Maria C Tartaglia, M.D.Principal InvestigatorToronto Western Hospital, UHN; Tanz CRND
2 Previous Clinical Trials
220 Total Patients Enrolled
~271 spots leftby Nov 2026
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