The First Therapeutic Intervention in Malignant Pleural Effusion Trial
(TIME-1 Trial)
Trial Summary
What is the purpose of this trial?
Fluid caused by cancer cells may accumulate in the lining of the lung. Draining the fluid with a chest tube may relieve pain and shortness of breath. To stop the fluid from coming back again, patients are given a medicine (talc) into the chest drain to seal up the space around the lung. This procedure is known as pleurodesis. This sometimes causes pain and discomfort, and the investigators do not know the best way of preventing this. The investigators hope to find the best way to prevent pain during pleurodesis.
Research Team
RJO Davies, Dr.
Principal Investigator
Oxford Pleural Unit, Churchill Hospital, Oxford, England
Eligibility Criteria
Inclusion Criteria
Treatment Details
Interventions
- Large bore chest drain + NSAID based analgesic regimen (Procedure)
- Large bore chest drain + opiate based analgesic regimen (Procedure)
- Small bore chest drain + NSAID based analgesic regimen (Procedure)
- Small bore chest drain + opiate based analgesic regimen (Procedure)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor
Rakesh Dixit
University of California, Davis
Chief Executive Officer since 2024
PhD in Biochemistry and Molecular Biology from the University of California, Davis
Suresh Mahabhashyam
University of California, Davis
Chief Medical Officer since 2020
MD from Bangalore Medical College