Smart Antibiotic Use Prompt for Pneumonia

Recruiting in Palo Alto (17 mi)

+58 other locations

Overseen by Susan Huang, MD, MPH

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Harvard Pilgrim Health Care

No Placebo Group

Trial Summary

What is the purpose of this trial?

The INSPIRE-ASP PNA trial is a cluster-randomized controlled trial of HCA hospitals comparing routine empiric antibiotic stewardship practices with real-time precision medicine computerized physician order entry smart prompts providing the probability that a non-critically ill adult admitted with PNA is infected with a resistant pathogen. Note: that enrolled "subjects" represents 59 individual HCA hospitals that have been randomized.

Research Team

Richard Platt, MD, MS

Principal Investigator

Harvard Pilgrim Health Care Institute

Susan Huang, MD, MPH

Principal Investigator

UC Irvine Div Infectious Diseases

Shruti Gohil, MD, MPH

Principal Investigator

UC Irvine Div Infectious Diseases

Eligibility Criteria

The INSPIRE-ASP PNA Trial is for HCA hospitals using MEDITECH electronic health records, admitting non-critically ill adults with pneumonia. It's not about individual patients but the facilities themselves.

Inclusion Criteria

The clinical trial is for adults with pneumonia who are admitted to HCA hospitals.

The medical facility uses MEDITECH as their electronic health record system.

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Treatment Details

Interventions

• INSPIRE CPOE Smart Prompt (Antibiotic Stewardship)
• Routine Care (Other)

Trial Overview This trial tests routine care against a smart system that tells doctors the chance of a pneumonia patient having a resistant infection. Hospitals are randomly chosen to use either standard methods or this new computer prompt.

Participant Groups

Group I: INSPIRE CPOE Smart Prompt Active Control 1 Intervention

Use of a computerized physician order entry (CPOE) smart prompt alert to guide empiric choice of antibiotics for PNA in non-ICU patients in the first 3 days of hospitalization.

Group II: Routine Care Active Control 1 Intervention

Continued routine antibiotic stewardship strategies.

Who Is Running the Clinical Trial?

Harvard Pilgrim Health Care

Lead Sponsor

Trials

61

Recruited

27,990,000+

Cain Hayes

Harvard Pilgrim Health Care

Chief Executive Officer since 2021

MBA from Webster University

Michael Sherman

Harvard Pilgrim Health Care

Chief Medical Officer since 2018

MD from Yale School of Medicine

Hospital Corporation of America

Industry Sponsor

Trials

8

Recruited

3,433,000+

Hospital Corporation of America Healthcare (HCA)

Collaborator

Trials

2

Recruited

100,000+

Centers for Disease Control and Prevention

Collaborator

Trials

902

Recruited

25,020,000+

Dr. Debra Houry

Centers for Disease Control and Prevention

Chief Medical Officer

MD, MPH

Dr. Susan Monarez

Centers for Disease Control and Prevention

Chief Executive Officer

PhD

Brigham and Women's Hospital

Collaborator

Trials

1,694

Recruited

14,790,000+

Dr. William Curry

Brigham and Women's Hospital

Chief Medical Officer

MD from Columbia University College of Physicians and Surgeons

Dr. Scott Schissel

Brigham and Women's Hospital

Chief Executive Officer since 2021

MD from Columbia University College of Physicians and Surgeons

University of Massachusetts, Amherst

Collaborator

Trials

83

Recruited

3,474,000+

Martin T. Meehan

University of Massachusetts, Amherst

Chief Executive Officer since 2015

J.D. from Suffolk University Law School

Dr. Mark Klempner

University of Massachusetts, Amherst

Chief Medical Officer since 2012

MD from McGill University

University of California, Irvine

Collaborator

Trials

580

Recruited

4,943,000+

Chad T. Lefteris

University of California, Irvine

Chief Executive Officer since 2019

MBA from University of California, Irvine

Michael J. Stamos

University of California, Irvine

Chief Medical Officer since 2019

MD, PhD from University of California, Irvine