High Definition NBI Colonoscopy for Colorectal Cancer (NBI Trial)

N/A

Waitlist Available

Led By Tonya Kaltenbach, MD MS

Research Sponsored by VA Palo Alto Health Care System

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

* Adult patients referred for routine colonoscopy are eligible

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up one week (time of procedure plus time for pathology of polyp to be analyzed by histology)

Summary

We hypothesize that high definition narrow band imaging (NBI) colonoscopy compared to high definition white light colonoscopy will detect an increased number of nonpolypoid (flat and depressed) colorectal neoplasm.

Eligible Conditions

Colorectal Cancer
Colonic Polyps

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ one week (time of procedure plus time for pathology of polyp to be analyzed by histology)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~one week (time of procedure plus time for pathology of polyp to be analyzed by histology)

This trial's timeline: 3 weeks for screening, Varies for treatment, and one week (time of procedure plus time for pathology of polyp to be analyzed by histology) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Number of Participants With Nonpolypoid (Flat and Depressed) Colorectal Neoplasm

Secondary study objectives

Colonoscopy

Percentage of Nonpolypoid (Flat) Missed Lesions

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: High Definition NBI ColonoscopyExperimental Treatment1 Intervention

Use of high definition narrow band imaging colonoscopy during examination for polyp detection. The same intervention is used on both arms: the Olympus Colonoscope CFHQ190AL, a technically improved colonoscope with close focus high definition narrow band imaging.

Group II: High Definition White Light ColonoscopyPlacebo Group1 Intervention

Use of high definition white light colonoscopy during examination for polyp detection. The same intervention is used on both arms: the Olympus Colonoscope CFHQ190AL, a technically improved colonoscope with close focus high definition narrow band imaging.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Olympus Colonoscope CFHQ190AL

2013

N/A

~290

0 / 1Eligibility criteria met