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Sweeteners for Prediabetes

N/A
Waitlist Available
Led By Richard Mattes, PhD
Research Sponsored by Purdue University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adults aged between 18 to 70 years old will be eligible to participate
No history of major surgeries, organ transplantations, or significant medical interventions that might impact glycemia
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 days
Awards & highlights
No Placebo-Only Group

Summary

"This trial will look at how blood sugar levels change after trying different sweeteners, using a device that continuously monitors glucose levels."

Who is the study for?
This trial is for healthy adults aged 18 to 70 without diabetes, heart disease, metabolic disorders, or other chronic conditions affecting blood sugar. Participants should not have had major surgeries or be on medications that alter glucose metabolism or taste perception.
What is being tested?
The study tests how different sweeteners (sucralose and sucrose) and controls (salt, water, no stimulation) affect blood sugar levels using continuous glucose monitoring in people with prediabetes.
What are the potential side effects?
Since the interventions involve only tasting sweeteners without ingestion, side effects are minimal but may include potential changes in appetite or minor digestive discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 70 years old.
Select...
I haven't had major surgeries or procedures that could affect my blood sugar levels.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Blood glucose concentration

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

5Treatment groups
Experimental Treatment
Group I: Oral Water StimulationExperimental Treatment1 Intervention
Oral stimulation with water.
Group II: Oral Sucrose stimulationExperimental Treatment2 Interventions
Oral stimulation with sucrose.
Group III: Oral Sucralose StimulationExperimental Treatment1 Intervention
Oral stimulation with sucralose.
Group IV: Oral Salt StimulationExperimental Treatment1 Intervention
Oral stimulation with salt.
Group V: No Oral StimulationExperimental Treatment1 Intervention
No oral stimulation is provided.

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Who is running the clinical trial?

Purdue UniversityLead Sponsor
233 Previous Clinical Trials
71,343 Total Patients Enrolled
Richard Mattes, PhDPrincipal InvestigatorPurdue University
1 Previous Clinical Trials
120 Total Patients Enrolled
~18 spots leftby Dec 2025
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