Biomarker Repository for Brain Cancer

Overseen By Linda Kaltenbach, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Duke University

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 1 Jurisdiction This treatment is already approved in other countries

Compensation: Varies

Number of Visits: Unknown

300 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to gather blood samples from individuals with primary or metastatic brain tumors. Researchers will use the collected samples to gain a better understanding of the disease, potentially leading to improved treatments in the future. Those diagnosed with a brain tumor, whether originating in the brain or spreading from another part of the body, might be suitable for this trial. Participants will only need to provide blood samples, ensuring a non-invasive process. As an unphased study, this trial offers a unique opportunity to contribute to groundbreaking research that could shape future treatments.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications.

What prior data suggests that blood sample collection is safe?

Research has shown that taking a blood sample is a common procedure with some minor risks. According to the World Health Organization, a bruise may form where the needle enters. If safety steps are not followed, there is also a small chance of infection. Health professionals use clean needles and gloves to prevent this.

Overall, the process is safe when performed correctly. Tools such as safety needles and proper disposal methods enhance safety. While minor risks exist, blood sample collection is generally safe and well-tolerated. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about this trial because it focuses on collecting blood samples to find circulating biomarkers for brain tumors. Unlike traditional methods that often rely on invasive biopsies or imaging to assess brain tumors, this approach aims to provide a less invasive way to gather crucial information about the tumor. By analyzing these biomarkers, researchers hope to improve diagnosis, monitor disease progression, and potentially tailor treatments more effectively. This could lead to more personalized treatment plans and better outcomes for patients with primary and metastatic brain tumors.

Who Is on the Research Team?

Eugene Vaios, MD MBA

Principal Investigator

Duke University Health System (DUHS)

Are You a Good Fit for This Trial?

Inclusion Criteria

Have a confirmed diagnosis of primary or metastatic brain tumor (histology or imaging as appropriate)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Radiation Therapy

Participants undergo radiation therapy as part of their treatment for brain tumors

6 weeks

Follow-up

Participants are monitored for safety and effectiveness after radiation therapy

6 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Blood Sample Collection

Who Is Running the Clinical Trial?

Duke University

Lead Sponsor

Trials

2,495

Recruited

5,912,000+

Citations

1.

who.int

who.int/publications/i/item/9789241599221

WHO guidelines on drawing blood: best practices in ...

Patients may be bruised. Health workers may receive needle-stick injuries. Both can become infected with bloodborne organisms such as hepatitis ...

2.

ncbi.nlm.nih.gov

ncbi.nlm.nih.gov/books/NBK574569/

Phlebotomy - StatPearls - NCBI Bookshelf

The basic tools required for a successful and safe blood draw include a tourniquet, an appropriate needle, gloves, alcohol wipes, and the ...

3.

cdc.gov

cdc.gov/dpdx/diagnosticprocedures/blood/safety.html

DPDx - Diagnostic Procedures - Blood Specimens

Blood Specimens – Safety · Wear personal protective equipment such as safety glasses, gloves, laboratory coats. · If you have cuts or abrasions on the skin of ...

4.

dhs.kerala.gov.in

dhs.kerala.gov.in/wp-content/uploads/2020/06/adph_27052018c.pdf

WHO guidelines on drawing blood:

This can be achieved by improving sharps disposal, and by using safety needles with needle covers or retractable needles to minimize the risk of exposure to ...

5.

brooklinecollege.edu

brooklinecollege.edu/blog/step-by-step-guide-to-venipuncture/

Step-by-Step Guide to Venipuncture | Risks & Requirements

In this guide, we'll walk you through what you need to know about venipuncture—from steps and techniques to risks and best practices ...