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Radiation Therapy

MRI-Guided Radiotherapy for Prostate Cancer

N/A
Waitlist Available
Led By Dian Wang, MD, PhD
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Acute bacterial or fungal infection requiring IV antibiotics
Prior chemotherapy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18 months
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing two different radiotherapy regimens for prostate cancer, one for patients without identifiable lesions and one for those with lesions, using MRI to guide treatment.

Who is the study for?
This trial is for men with prostate cancer diagnosed within the last year, who are in good physical condition (able to carry out daily activities without significant limitations). They must not have cancer spread to lymph nodes or distant sites, no history of pelvic radiation, severe illnesses like heart disease or uncontrolled infections, and they can't have had prior chemotherapy or other invasive cancers except skin cancer.
What is being tested?
The study tests two radiotherapy approaches using MRI guidance. Men without visible lesions get a short course of SBRT to the whole prostate. Those with lesions receive longer IMRT treatment followed by an intense SBRT boost specifically targeting the identified lesions.
What are the potential side effects?
Potential side effects include urinary issues such as increased frequency and discomfort, bowel changes like diarrhea, fatigue during treatment weeks, and possible sexual dysfunction due to radiation affecting nearby tissues.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am currently on IV antibiotics for a serious bacterial or fungal infection.
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I have had chemotherapy before.
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I do not have severe heart, lung, liver diseases, or AIDS.
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I have or had cancer other than non-melanoma skin cancer.
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My cancer has spread to nearby lymph nodes.
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My cancer has spread to distant parts of my body.
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I have had radiation therapy to my pelvic area before.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 18 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of Participants With Late Radiation Induced Genitourinary and Gastrointestinal Toxicity
Secondary study objectives
Biochemical Recurrence
Disease Free-Survival
Number of Participants With Acute Radiation Induced Genitourinary Adverse Event

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Positive mpMRI Prostate ScanExperimental Treatment1 Intervention
IMRT to the prostate + seminal vesicles followed by SBRT boost to the whole prostate with SIB to MRI defined intraprostatic lesions
Group II: Negative mpMRI Prostate ScanExperimental Treatment1 Intervention
SBRT to the whole prostate

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
436 Previous Clinical Trials
249,310 Total Patients Enrolled
Dian Wang, MD, PhDPrincipal InvestigatorRush University Medical Center
1 Previous Clinical Trials
98 Total Patients Enrolled

Media Library

IMRT followed by mpMRI guided SBRT boost with SIB to intraprostatic lesions (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03778112 — N/A
Prostate Cancer Research Study Groups: Negative mpMRI Prostate Scan, Positive mpMRI Prostate Scan
Prostate Cancer Clinical Trial 2023: IMRT followed by mpMRI guided SBRT boost with SIB to intraprostatic lesions Highlights & Side Effects. Trial Name: NCT03778112 — N/A
IMRT followed by mpMRI guided SBRT boost with SIB to intraprostatic lesions (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03778112 — N/A
~6 spots leftby Nov 2025
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