Improved MRI Techniques for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests improvements to MRI technology to determine if it can better capture images of blood vessels and tissue without contrast dye. The goal is to discover whether these new methods can make MRI scans clearer and more useful for doctors. This is particularly relevant for individuals who require regular MRI scans and wish to avoid contrast dye. Adults who need MRI scans and prefer ones without dye might be suitable candidates for this trial. As an unphased study, this trial provides a unique opportunity to contribute to advancements in MRI technology that could benefit many patients in the future.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that these improved MRI techniques are safe for prostate cancer patients?
Research has shown that MRI (Magnetic Resonance Imaging) is generally safe for patients. One study used MRI to help diagnose prostate cancer and reported no major safety problems. Another study found MRI useful in treating prostate cancer, with no serious side effects noted.
MRI does not use radiation, making it safer than imaging methods like X-rays or CT scans. Overall, these studies indicate that MRI is well-tolerated and poses a low risk of harm.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores improvements in MRI techniques, particularly Dynamic Contrast-Enhanced MR Angiography and non-contrast MRI. Unlike traditional MRIs that often require contrast agents to enhance image clarity, this trial focuses on non-contrast methods, reducing potential risks for patients who have allergies or kidney issues. This approach could make MRIs safer and more comfortable, expanding accessibility for individuals who currently face limitations due to the need for contrast agents. By enhancing image quality without contrast, the trial aims to improve diagnostic accuracy and patient outcomes.
What evidence suggests that these improved MRI techniques are effective for prostate cancer?
Research has shown that MRI is a valuable tool for managing prostate cancer. Studies have found that MRI can detect and diagnose significant cases of prostate cancer more accurately. For instance, using MRI before a biopsy reduces unnecessary diagnoses of less serious cancers. One study discovered that a special MRI method, called restriction spectrum imaging, significantly improves the detection of aggressive cancer. Overall, MRI aids in identifying and monitoring prostate cancer more effectively, potentially leading to better outcomes. Participants in this trial will undergo a non-contrast MRI to evaluate these improved techniques.678910
Who Is on the Research Team?
Stephen J. Riederer, PhD
Principal Investigator
Mayo Clinic in Rochester
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Observational
Participants undergo a non-contrast MRI on study and may optionally undergo a second non-contrast MRI. Blood samples may also be collected.
Follow-up
Participants are monitored for safety and effectiveness after the MRI procedures
What Are the Treatments Tested in This Trial?
Interventions
- MRI
How Is the Trial Designed?
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Treatment groups
Experimental Treatment
Participants undergo a non-contrast MRI on study and may optionally undergo a second non-contrast MRI on study. Participants may also undergo blood sample collection on study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Collaborator
Citations
The Role of MRI in Prostate Cancer, Current and Future ...
MRI plays key roles in many steps of prostate cancer management, including detection and diagnosis, MRI-guided biopsy, staging, active surveillance, treatment ...
Results after Four Years of Screening for Prostate Cancer ...
In this trial, omitting biopsy in patients with negative MRI results eliminated more than half of diagnoses of clinically insignificant prostate cancer.
Magnetic Resonance Imaging Before Biopsy in Screening ...
Compared with no screening, MRI-first age-based screening was associated with 36 910 (95% CI, 33 720-40 040) fewer deaths from prostate cancer ...
4.
news.uthscsa.edu
news.uthscsa.edu/ut-health-san-antonio-study-shows-mri-technique-improves-detection-of-aggressive-prostate-cancer-2/UT Health San Antonio study shows MRI technique ...
An MRI scan called restriction spectrum imaging greatly improves the detection of prostate cancer progression, according to a published study.
Magnetic Resonance Imaging–based Biopsy Strategies in ...
This review found that magnetic resonance imaging (MRI) scans can enhance the selective detection of significant prostate cancer cases while safely decreasing ...
Oncological Safety of MRI-Informed Biopsy Decision ...
This cohort study assesses the feasibility and safety of a community-based magnetic resonance imaging (MRI) diagnostic strategy in men with suspected prostate ...
Prostate Cancer Salvage Magnetic Resonance Imaging ...
At 12 mo, 89% showed no cancer in the targeted area, with a median PSA reduction of 95% (p < 0.001). Five-year metastasis-free, failure-free, and biochemical ...
Prostate Cancer Screening with PSA and MRI Followed by ...
Prostate cancer screening with magnetic resonance imaging: results from the second round of the Göteborg Prostate Cancer Screening 2 trial.
Evolution of Active Surveillance of Prostate Cancer
When men enter AS with low-risk PCa diagnosed by MRGB, subsequent biopsy can be safely avoided when MRI is negative. For men entering AS with ...
10.
auanet.org
auanet.org/guidelines-and-quality/guidelines/other-clinical-guidance/mri-of-the-prostate-sopProstate Cancer
Multi-parametric MRI (mpMRI) has been proven to be a valuable tool in the diagnostic and management pathway in men at risk of prostate cancer.
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