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Visual Perceptual Remediation for Schizophrenia (VRiS Trial)

N/A
Waitlist Available
Led By Steven M Silverstein, Ph.D.
Research Sponsored by University of Rochester
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
SCID-5 diagnosis of schizophrenia
Aged 18-60
Must not have
History of brain trauma associated with loss of consciousness for > 10 minutes or behavioral sequelae
History of eye disease (e.g., glaucoma, retinopathy)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up years 3-5
Awards & highlights
No Placebo-Only Group

Summary

This trial will evaluate the effectiveness of different interventions targeting visual functions that are often impaired in people with schizophrenia. The study will compare the effects of the interventions to a control condition of higher-level cognitive remediation. Outcome measures include multiple aspects of visual functioning, as well as visual cognition and overall community functioning.

Who is the study for?
This trial is for individuals aged 18-60 with a diagnosis of schizophrenia, who speak English and can complete basic cognitive tests. They should be clinically stable with no recent medication changes and have at least a 6th-grade reading level. People with eye diseases, recent substance abuse, intellectual disabilities, or significant brain trauma are not eligible.
What is being tested?
The study evaluates the effectiveness of visual remediation interventions for schizophrenia patients. It examines contrast sensitivity and perceptual organization through UltimEyes + Contour Integration Training versus each method alone or MyBrainSolutions as control. The best approach from phase one will undergo further testing in phase two.
What are the potential side effects?
While specific side effects are not detailed for these non-pharmaceutical interventions, participants may experience fatigue or discomfort from focusing on visual tasks during the training sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with schizophrenia.
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I am between 18 and 60 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had a head injury that made me unconscious for more than 10 minutes.
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I have a history of eye disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~years 3-5
This trial's timeline: 3 weeks for screening, Varies for treatment, and years 3-5 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Contour integration
Contrast sensitivity - behavioral
Contrast sensitivity - electrophysiological
Secondary study objectives
Cognition
Community functioning
Emotion recognition
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Perceptual organizationExperimental Treatment1 Intervention
Contour Integration Training
Group II: Contrast sensitivity + Perceptual org.Experimental Treatment1 Intervention
UltimEyes + Contour Integration Training
Group III: Contrast sensitivityExperimental Treatment1 Intervention
UltimEyes
Group IV: Cognitive remediationActive Control1 Intervention
MyBrainSolutions

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,918 Previous Clinical Trials
2,739,886 Total Patients Enrolled
254 Trials studying Schizophrenia
89,952 Patients Enrolled for Schizophrenia
University of RochesterLead Sponsor
867 Previous Clinical Trials
548,803 Total Patients Enrolled
1 Trials studying Schizophrenia
180 Patients Enrolled for Schizophrenia
Weill Medical College of Cornell UniversityOTHER
1,085 Previous Clinical Trials
1,147,243 Total Patients Enrolled
7 Trials studying Schizophrenia
250 Patients Enrolled for Schizophrenia

Media Library

Contour Integration Training Clinical Trial Eligibility Overview. Trial Name: NCT03314129 — N/A
Schizophrenia Research Study Groups: Contrast sensitivity + Perceptual org., Contrast sensitivity, Perceptual organization, Cognitive remediation
Schizophrenia Clinical Trial 2023: Contour Integration Training Highlights & Side Effects. Trial Name: NCT03314129 — N/A
Contour Integration Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT03314129 — N/A
~4 spots leftby Mar 2025
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