Neurophysiologic Biomarkers in Rett Syndrome
Recruiting in Palo Alto (17 mi)
+5 other locations
Overseen ByEric Marsh, MD, PhD
Age: < 65
Sex: Female
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Children's Hospital of Philadelphia
No Placebo Group
Trial Summary
What is the purpose of this trial?The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are:
* Do these biomarkers change during clinical changes in individuals with RTT?
* Are biomarkers stable over time in clinically stable individuals?
* Do these biomarkers correlate with severity of RTT?
Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity in the brain.
Researchers will compare findings in individuals with RTT to those in typically developing individuals to see if there are differences between the two groups.
Eligibility Criteria
Participant Groups
2Treatment groups
Experimental Treatment
Group I: RTT FemalesExperimental Treatment2 Interventions
Females with Rett Syndrome
Group II: ControlsExperimental Treatment1 Intervention
Females with typical development
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
Children's Hospital of PhiladelphiaPhiladelphia, PA
Texas Children's HospitalHouston, TX
Vanderbilt University Medical CenterNashville, TN
Children's Hospital ColoradoAurora, CO
More Trial Locations
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Who is running the clinical trial?
Children's Hospital of PhiladelphiaLead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)Collaborator
Vanderbilt University Medical CenterCollaborator