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RTT Females for Rett Syndrome

N/A
Recruiting
Led By Eric Marsh, MD, PhD
Research Sponsored by Children's Hospital of Philadelphia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

Summary

The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individuals? * Do these biomarkers correlate with severity of RTT? Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity in the brain. Researchers will compare findings in individuals with RTT to those in typically developing individuals to see if there are differences between the two groups.

Eligible Conditions
  • Rett Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Auditory Evoked Potential (AEP) amplitude
Auditory Evoked Potential (AEP) latency (ms)
EEG Analysis
+2 more
Secondary study objectives
AEP spectral analysis, dipole determination and spatial distribution
VEP spectral analysis, dipole determination and spatial distribution

Trial Design

2Treatment groups
Experimental Treatment
Group I: RTT FemalesExperimental Treatment2 Interventions
Females with Rett Syndrome
Group II: ControlsExperimental Treatment1 Intervention
Females with typical development

Find a Location

Who is running the clinical trial?

National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,362 Previous Clinical Trials
650,548 Total Patients Enrolled
3 Trials studying Rett Syndrome
1,942 Patients Enrolled for Rett Syndrome
Children's Hospital of PhiladelphiaLead Sponsor
721 Previous Clinical Trials
8,604,125 Total Patients Enrolled
4 Trials studying Rett Syndrome
8,195 Patients Enrolled for Rett Syndrome
Vanderbilt University Medical CenterOTHER
888 Previous Clinical Trials
934,732 Total Patients Enrolled
3 Trials studying Rett Syndrome
8,023 Patients Enrolled for Rett Syndrome
~135 spots leftby Mar 2028
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