Weight Loss and Exercise for Insulin Resistance in Aging

Recruiting in Palo Alto (17 mi)

Overseen byBret Goodpaster, PhD

Age: 65+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Translational Research Institute for Metabolism and Diabetes, Florida

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this study is to provide information regarding potential factors underlying metabolic dysfunction, insulin resistance, and loss of muscle mass in aging muscle.

Eligibility Criteria

The MIRAGE study is for older adults aged 65-80 who are overweight, sedentary, non-smokers with stable weight and blood pressure within certain limits. Those with diabetes must be able to monitor their own blood sugar after stopping medication for two weeks. People with recent heart attacks, vascular diseases, neuropathy or serious liver, kidney or muscle conditions cannot join.

Inclusion Criteria

Your blood pressure should be below 150/95 mmHg when measured at rest.

Your weight has not changed by more than 10 pounds in the past 6 months.

You do not engage in regular exercise, meaning you do not exercise at least once a week.

+5 more

Exclusion Criteria

I do not have active liver, kidney, muscle, or blood cancer conditions.

Weak pulse that a doctor can feel

You have abnormal sounds in your legs.

+4 more

Participant Groups

This trial investigates how energy restriction-induced weight loss and exercise can affect insulin resistance and muscle mass in aging individuals. It aims to uncover factors contributing to metabolic dysfunction in the elderly.

3Treatment groups

Experimental Treatment

Active Control

Group I: Exercise training protocolExperimental Treatment1 Intervention

Group II: Energy restriction-induced weight lossExperimental Treatment1 Intervention

Group III: Health EducationActive Control1 Intervention