Trial Summary
What is the purpose of this trial?Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.
Eligibility Criteria
This trial is for older adults who are experiencing muscle loss and weakness, known as sarcopenia. Participants should be interested in following a combined program of endurance and resistance training according to public health guidelines.Inclusion Criteria
I am 60 years old or older.
I do not have any long-term illnesses.
No structured exercise program (2 or more bouts/wk) within previous 12 months
+1 more
Exclusion Criteria
Life expectancy < 1 year
Lidocaine allergy
I do not have any current infections.
+10 more
Participant Groups
The study is testing how effective a combination of endurance and resistance exercises can be in improving the health and physical capabilities of older adults with sarcopenia. It aims to understand why people respond differently to exercise.
2Treatment groups
Experimental Treatment
Group I: MitigationExperimental Treatment1 Intervention
Based on these categories of responsiveness, exercise training will be boosted in the three groups that are nonresponsive in one or both outcomes. CRF-/fMQ+ will receive boosted ET, CRF+/fMQ- will receive boosted RT, and CRF-/fMQ- will receive boosting in both. All three of these classifications will also receive education on wearable device data and other free-living recommendations four times during Mitigation
Group II: InterrogationExperimental Treatment1 Intervention
In Interrogation, all participants will exercise train using an exercise prescription that is in accordance with current public health recommendations19. At the end of Phase I participants will be classified into one of the four categories listed in Fig. A: (1) CRF-/fMQ-, 2) CRF-/fMQ+, 3) CRF+/fMQ- and 4) CRF+/fMQ+).
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Oklahoma Medical Research FoundationOklahoma City, OK
Florida Institute for Human and Machine CognitionPensacola, FL
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Who Is Running the Clinical Trial?
Florida Institute for Human and Machine CognitionLead Sponsor
University of FloridaCollaborator
Oklahoma Medical Research FoundationCollaborator