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Resveratrol + Strength Training for Sarcopenia (STaR Trial)

N/A

Waitlist Available

Led By Danielle E Levitt, PhD

Research Sponsored by Texas Tech University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 60+

Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during pre-, mid-, and post-testing (each separated by about 6 weeks)

Summary

This trial aims to see if taking resveratrol can help improve muscle strength in adults over 60 when combined with strength training. The study will also look at how resveratrol may impact

Who is the study for?

This trial is for adults aged 60 and older who haven't done resistance training in the last 6 months, aren't taking resveratrol supplements, have stable medication and lifestyle habits with minimal activity levels (less than an hour of structured exercise per week).

What is being tested?

The study tests if resveratrol supplements can boost muscle strength gains from resistance training in seniors. It also looks at how this might affect blood vessel and brain health by studying extracellular vesicles.

What are the potential side effects?

Possible side effects of resveratrol may include gastrointestinal issues like nausea or diarrhea, headache, dizziness, and skin reactions. Resistance training could cause muscle soreness or injury if not performed correctly.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 60 years old or older.

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My daily habits and medications have been the same for the last 3 months and I don't plan to change them.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during pre-, mid-, and post-testing (each separated by about 6 weeks)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during pre-, mid-, and post-testing (each separated by about 6 weeks)

This trial's timeline: 3 weeks for screening, Varies for treatment, and during pre-, mid-, and post-testing (each separated by about 6 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Appendicular skeletal muscle mass index

Circulating extracellular vesicle microRNA profile

Muscle fatigability

+2 more

Secondary study objectives

Cognitive function

Gait speed

Grip strength

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Resveratrol (RSV) groupExperimental Treatment2 Interventions

Participants will be randomized to consume resveratrol (500 mg) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

Group II: PlaceboPlacebo Group2 Interventions

Participants will be randomized to consume placebo capsules (cellulose, visually identical to resveratrol capsules) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Resistance training

2008

Completed Phase 3

~1010

0 / 2Eligibility criteria met