Trial Summary
What is the purpose of this trial?The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.
Eligibility Criteria
This trial is for adults aged 60 and older who haven't done resistance training in the last 6 months, aren't taking resveratrol supplements, have stable medication and lifestyle habits with minimal activity levels (less than an hour of structured exercise per week).Inclusion Criteria
I am 60 years old or older.
I am not taking resveratrol supplements.
Minimally active (less than 1 hour of structured exercise/week other than walking)
+2 more
Exclusion Criteria
I don't have health issues that make exercise risky for me.
Cannabis or nicotine use
Consume more than 7 alcohol-containing beverages per week
Participant Groups
The study tests if resveratrol supplements can boost muscle strength gains from resistance training in seniors. It also looks at how this might affect blood vessel and brain health by studying extracellular vesicles.
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Resveratrol (RSV) groupExperimental Treatment2 Interventions
Participants will be randomized to consume resveratrol (500 mg) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.
Group II: PlaceboPlacebo Group2 Interventions
Participants will be randomized to consume placebo capsules (cellulose, visually identical to resveratrol capsules) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Department of Kinesiology & Sport Management, Texas Tech UniversityLubbock, TX
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Who Is Running the Clinical Trial?
Texas Tech UniversityLead Sponsor
National Strength and Conditioning Association FoundationCollaborator