Repetitive Transcranial Magnetic Stimulation (rTMS) for Schizophrenia

N/A

Waitlist Available

Led By Michael Avissar, MD, PhD

Research Sponsored by Columbia University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and 4 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing a treatment that uses magnetic pulses to change brain activity on patients with schizophrenia who hear voices and don't respond well to other treatments. The goal is to see if this method can reduce these hallucinations by adjusting brain activity in specific areas. This non-invasive treatment has been studied for many years as a potential solution for auditory hallucinations in schizophrenia, showing promising but variable results.

Eligible Conditions

Schizophrenia

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and 4 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and 4 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 4 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Total Number of Treatment Emergent Adverse Events

Total Number of rTMS Sessions Completed

Secondary study objectives

Change in Auditory Hallucination Rating Scale (AHRS)

Change in Cardiff Anomalous Perceptions Scale (CAPS)

Change in Positive and Negative Syndrome Scale (PANSS)- General Psychopathology

+8 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Individualized magnetic resonance imaging (MRI) guided rTMSExperimental Treatment1 Intervention

Participants will receive a type of TMS called repetitive TMS (rTMS) wherein the magnetic pulses delivered will be close together in a rapid sequence. They will receive a 20-min once-daily rTMS sessions over a period of 2 weeks (weekends off), and therefore accrue a total of 10 rTMS stimulation sessions. The rTMS parameters that will be used are a frequency of 1 Hz (1 pulse per second) at an intensity of 90% of the motor threshold (MT). Therefore, the investigators will deliver 1200 continuous pulses per session/day which adds up to 12,000 pulses in total for the whole treatment.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Repetitive Transcranial Magnetic Stimulation (rTMS)

2019

Completed Phase 2

~780

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