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Social Stress Test for Social Anxiety (SSBI Trial)

N/A
Waitlist Available
Led By John D.E. Gabrieli, PhD
Research Sponsored by Massachusetts Institute of Technology
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1
Awards & highlights
No Placebo-Only Group

Summary

This trial looks at how stress affects the brain, and whether it affects how we think and feel.

Who is the study for?
This trial is for healthy English-speaking adults aged 18-55 who can consent to participate. They must be right-handed, not pregnant, drug-free, and without significant mental health issues or severe medical conditions. Participants should not have used certain medications recently and must pass a social anxiety scale test.
What is being tested?
The study is testing how experiencing social stress affects brain activity in healthy individuals. It uses the Trier Social Stress Test (TSST) followed by neuroimaging to observe changes in brain activation patterns.
What are the potential side effects?
Since this trial involves a stress test and MRI scans, side effects may include temporary stress-related responses such as increased heart rate or anxiety during the TSST, and discomfort or claustrophobia during MRI scanning.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Differences in fMRI BOLD Response

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Film + TSSTExperimental Treatment1 Intervention
Nature Film + Trier Social Stress Test (TSST)
Group II: Film Only (No-TSST)Active Control1 Intervention
Nature Film Only
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Trier Social Stress Test (TSST)
2020
N/A
~210

Find a Location

Who is running the clinical trial?

Massachusetts Institute of TechnologyLead Sponsor
98 Previous Clinical Trials
12,819,937 Total Patients Enrolled
Massachusetts General HospitalOTHER
3,014 Previous Clinical Trials
13,309,281 Total Patients Enrolled
John D.E. Gabrieli, PhDPrincipal InvestigatorMassachusetts Institute of Technology
1 Previous Clinical Trials
50 Total Patients Enrolled

Media Library

Film + TSST Clinical Trial Eligibility Overview. Trial Name: NCT05591404 — N/A
Social Anxiety Research Study Groups: Film + TSST, Film Only (No-TSST)
Social Anxiety Clinical Trial 2023: Film + TSST Highlights & Side Effects. Trial Name: NCT05591404 — N/A
Film + TSST 2023 Treatment Timeline for Medical Study. Trial Name: NCT05591404 — N/A
~31 spots leftby May 2025
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