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Radiation Therapy

Temporally Feathered Radiation Therapy (TFRT) for Head and Neck Cancers

N/A
Waitlist Available
Led By Nikhil Joshi, MD
Research Sponsored by Case Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at weeks 1, 4, and 7 of treatment and at 2 weeks, 4 weeks, and 3 months post-treatment
Awards & highlights

Summary

This study will evaluate the feasibility of using more advanced IMRT (intensity modulated radiation therapy) techniques. This new technique is termed Temporally Feathered Radiation Therapy (TFRT). TFRT is designed to reduce the side effects of conventional radiation therapy. Research has shown that TFRT may lessen these side effects.

Eligible Conditions
  • Head and Neck Cancers

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at week 1, 4, and 7 of treatment and at 2 weeks, 4 weeks, and 3 months post-treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and at week 1, 4, and 7 of treatment and at 2 weeks, 4 weeks, and 3 months post-treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility of TFRT Planning and Delivery Defined by Number of Participants Starting Radiotherapy Within 15 Days of Simulation
Secondary outcome measures
Number of Participants Considered Compliant With Plan Delivery
Number of Participants Who Experienced Grade 3-5 Acute Toxicities Per CTCAE Version 4
Participant-reported Outcomes (PRO) During TFRT Using EORTC QLQ-C30 Questionnaire
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Temporally Feathered Radiation Therapy (TFRT)Experimental Treatment1 Intervention
Temporally feathered radiation therapy is designed for targets within close proximity to multiple organs at risk. The foundation of this planning technique is the rotation of radiation dose to the nearby organs at risk on a daily basis, and hence the term "feathering".
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Temporally Feathered Radiation Therapy (TFRT)
2018
N/A
~10

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Who is running the clinical trial?

Case Comprehensive Cancer CenterLead Sponsor
462 Previous Clinical Trials
32,558 Total Patients Enrolled
Nikhil Joshi, MDPrincipal InvestigatorThe Cleveland Clinic
~1 spots leftby Sep 2025
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