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Behavioral Intervention

Guilt Reduction vs Exposure Therapy for PTSD (PORT Trial)

N/A
Waitlist Available
Led By Shannon Kehle-Forbes, PhD
Research Sponsored by Veterans Medical Research Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 8-, 16-, and 28 weeks after the first therapy session
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to compare the effectiveness of Trauma-Informed Guilt Reduction (TrIGR) Therapy and Prolonged Exposure Therapy in veterans with PTSD and trauma-related guilt. It wants to

Who is the study for?
This trial is for veterans with PTSD who feel guilt or shame related to their trauma. Participants must be diagnosed with PTSD and have experienced a traumatic event that causes them feelings of guilt.
What is being tested?
The study compares Trauma-Informed Guilt Reduction (TrIGR) Therapy with Prolonged Exposure (PE) Therapy to see which is better at reducing PTSD symptoms, improving overall functioning, and lessening feelings of guilt and shame.
What are the potential side effects?
While the therapies being tested are not drugs, they may cause emotional discomfort due to recalling traumatic events. Some participants might experience increased anxiety or sadness during treatment.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 8-, 16-, and 28 weeks after the first therapy session
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 8-, 16-, and 28 weeks after the first therapy session for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Clinician Administered PTSD Scale for DSM-5 (CAPS-5)
Secondary study objectives
Brief Psychosocial Functioning Inventory (B-IPF)
Patient Health Questionnaire-9 (PHQ-9)
Trauma Related Guilt Inventory Cognitions Scale (TRGI)
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: trauma Informed Guilt Reduction TherapyExperimental Treatment1 Intervention
6 session behavioral intervention focused on trauma-related guilt, shame, and moral injury
Group II: Prolonged Exposure TherapyActive Control1 Intervention
12 session behavioral intervention focused on PTSD symptoms

Find a Location

Who is running the clinical trial?

University of MinnesotaOTHER
1,436 Previous Clinical Trials
1,621,525 Total Patients Enrolled
Veterans Medical Research FoundationLead Sponsor
44 Previous Clinical Trials
4,859 Total Patients Enrolled
Center for Veterans Research and EducationOTHER
12 Previous Clinical Trials
1,498 Total Patients Enrolled
Shannon Kehle-Forbes, PhDPrincipal InvestigatorUniversity of Minnesota
2 Previous Clinical Trials
626 Total Patients Enrolled
~105 spots leftby Jul 2027
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