Cognitive Processing Therapy for PTSD and Opioid Use Disorder
(OPTIMO Trial)

Recruiting in Palo Alto (17 mi)

Overseen byTeresa Lopez-Castro, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: The City College of New York

No Placebo Group

Trial Summary

What is the purpose of this trial?The goal of this open pilot trial is to learn if an adapted version of Cognitive Processing Therapy (CPT), delivered through telehealth, can treat posttraumatic stress disorder (PTSD) in adults who use syringe services programs. The main questions it aims to answer are: * Can the intervention be done in syringe services programs? * Are syringe services program clients and staff open to the intervention? * Can the intervention lower PTSD symptoms and help participants keep taking their medication for opioid use disorder (ex. Buprenorphine or methadone)? Participants will: * Attend 4-18 tele-delivered CPT sessions at the syringe services program * Complete between-session CPT practice with the support of SSP-based "coaches" * Meet with research staff monthly to complete surveys of their PTSD symptoms, drug use, and mental health

Eligibility Criteria

This trial is for adults with PTSD who also use syringe services programs and have an opioid use disorder. They must be willing to attend telehealth therapy sessions and work with coaches at the program. Specific details on inclusion or exclusion criteria are not provided.

Inclusion Criteria

Ability to provide informed consent

Regular syringe services program attendance (ex. at least 4 visits in the past month)

Meeting DSM-5 opioid use disorder criteria

+6 more

Exclusion Criteria

High risk for suicidal thoughts and/or behaviors that would make participation dangerous, as measured by the Columbia Suicide Severity Rating Scale Lifetime-Recent Screen

I have been diagnosed with a psychotic or bipolar disorder.

I am currently undergoing therapy for trauma.

+1 more

Participant Groups

The study tests if Cognitive Processing Therapy (CPT) adapted for telehealth can reduce PTSD symptoms in those using syringe services while helping them continue their medication for opioid use disorder, like Buprenorphine or methadone.

1Treatment groups

Experimental Treatment

Group I: Adapted Cognitive Processing TherapyExperimental Treatment1 Intervention

Participants will receive 4-18 sessions of telehealth-delivered Cognitive Processing Therapy (CPT) adapted for people who use syringe services programs. Participants will attend the 50-minute CPT sessions in a private space within the syringe services program.