CPT + Memory Enhancement for PTSD

Recruiting in Palo Alto (17 mi)

Overseen byJames C. Scott, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: VA Office of Research and Development

No Placebo Group

Trial Summary

What is the purpose of this trial?Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response in PTSD. However, limited research has examined methods for increasing learning of therapy contents in psychotherapy for PTSD. The proposed study aims to examine the feasibility of integrating an intervention to increase learning and memory of psychotherapy content into the provision of a widely used psychotherapy, cognitive processing therapy (CPT), for older adults with PTSD. The ultimate goal of this line of research is to develop novel rehabilitation interventions to increase functioning for individuals with PTSD.

Eligibility Criteria

This trial is for veterans over the age of 59 with PTSD diagnosed by a specific scale (CAPS-5). It's not suitable for those with severe brain injury, dementia signs, daily benzodiazepine use, bipolar or psychotic disorders, current serious suicidal thoughts, active substance abuse issues not in remission for at least a month, or other limiting conditions.

Inclusion Criteria

Veterans with DSM-5 diagnoses of PTSD via the Clinician Administered PTSD Scale (CAPS-5)

I am 60 years old or older.

Exclusion Criteria

I use benzodiazepines daily.

I have had a severe brain injury.

Current suicidal ideation with plan or intent

+4 more

Participant Groups

The study tests whether adding Memory Support to Cognitive Processing Therapy (CPT) can help older adults with PTSD learn and remember therapy content better. The goal is to improve how well they respond to treatment.

2Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive Processing Therapy (CPT) + Memory SupportExperimental Treatment2 Interventions

CPT+Memory support will also incorporate frequent and intentional use of strategies to enhance learning and memory of this content.

Group II: Cognitive Processing Therapy (CPT)Active Control1 Intervention

Standard CPT as described in the treatment manual

Cognitive Processing Therapy is already approved in United States, European Union for the following indications:

🇺🇸 Approved in United States as Cognitive Processing Therapy for: