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fMRI Predictors of Treatment Response in Posttraumatic Stress Disorder (PTSD)

N/A
Waitlist Available
Led By Yuval Neria, PhD
Research Sponsored by Research Foundation for Mental Hygiene, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 7, week 10, and 3 month follow up
Awards & highlights
No Placebo-Only Group

Summary

To employ a fear learning-extinction paradigm with functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) assessments among patients with posttraumatic stress disorder (PTSD) and trauma exposed healthy controls, aiming to a) clarify neural circuits underlying PTSD and b) to probe brain based predictors of symptomatic improvement in response to Prolonged Exposure (PE) treatment, and first line treatment for PTSD.

Eligible Conditions
  • Post-Traumatic Stress Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 7, week 10, and 3 month follow up
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 7, week 10, and 3 month follow up for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change over time in Clinician Administered PTSD Scale (CAPS)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Prolonged Exposure (PE) treatment.Experimental Treatment1 Intervention
Group II: Trauma exposed healthy controlsActive Control1 Intervention
Clinical assessments at baseline, 7 and 10 weeks. fMRI assessments at baseline and 10 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Prolonged Exposure (PE)
2014
Completed Phase 3
~1200

Find a Location

Who is running the clinical trial?

Harvard UniversityOTHER
233 Previous Clinical Trials
473,836 Total Patients Enrolled
University of Colorado, BoulderOTHER
124 Previous Clinical Trials
29,326 Total Patients Enrolled
Research Foundation for Mental Hygiene, Inc.Lead Sponsor
66 Previous Clinical Trials
20,713 Total Patients Enrolled
Yuval Neria, PhDPrincipal InvestigatorNew York State Psychiatric Institute
8 Previous Clinical Trials
7,697 Total Patients Enrolled
~6 spots leftby Jan 2026
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