1500 Participants Needed

System Improvement for Severe Stroke Care

TG
SK
Overseen ByShaila Kamal
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Alabama at Birmingham
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The trial aims to enhance the emergency care system for severe stroke patients, similar to trauma systems. It focuses on patients with large vessel occlusion (LVO), a type of stroke that blocks major blood vessels in the brain. The trial seeks to improve access to mechanical thrombectomy (MT)—a procedure that can significantly benefit LVO patients—by coordinating care across different regions. Individuals who may qualify have had a suspected severe stroke and were entered into Alabama's stroke system by emergency medical services (EMS). As an unphased trial, this study offers the opportunity to contribute to groundbreaking research that could transform stroke care systems.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Why are researchers excited about this trial?

Researchers are excited about the STROKE STAT trial because it aims to improve how quickly severe stroke patients receive treatment. Unlike traditional methods, which often involve a one-size-fits-all approach, this trial explores triaging patients based on stroke severity to speed up critical interventions like clot removal or clot-busting drugs. The hope is that by tailoring the response to the stroke's severity, patients will receive faster and more effective care, potentially improving outcomes and reducing long-term disabilities.

Who Is on the Research Team?

TG

Toby Gropen, MD

Principal Investigator

UAB Neurology

Are You a Good Fit for This Trial?

Inclusion Criteria

Patients entered into the Alabama stroke system by EMS
Suspected Large-Vessel Occlusion (score ≥ 4) based on a validated 6 item stroke severity scale, the Emergency Medical Stroke Assessment (EMSA)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Period

All stroke patients undergo standard triage to the nearest stroke center of any level

12 months

Implementation Period

Implementation of TCC Coordinated SBST where patients are routed to MTCs based on severity and transport time limits

24 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

3 months
Validated structured telephone mRS at 3 months post stroke

What Are the Treatments Tested in This Trial?

Interventions

  • No Intervention

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Stroke patientsExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alabama at Birmingham

Lead Sponsor

Trials
1,677
Recruited
2,458,000+

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborator

Trials
1,403
Recruited
655,000+