Prolonged Exposure Therapy for PTSD and Substance Use Disorder
(PREVAIL Trial)

Recruiting in Palo Alto (17 mi)

+3 other locations

Overseen byShannon Kehle-Forbes, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Veterans Medical Research Foundation

No Placebo Group

Approved in 3 Jurisdictions

Trial Summary

What is the purpose of this trial?The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. The main questions it aims to answer are: * Will the massed format help participants complete and benefit from Prolonged Exposure in terms of PTSD symptoms? * Will it help participants reduce substance use? Participants who are in intensive substance use treatment will be asked to complete Prolonged Exposure with either weekly sessions or multiple sessions per week.

Eligibility Criteria

This trial is for veterans with PTSD and substance use disorder who are currently in intensive outpatient treatment. Participants will be asked to complete Prolonged Exposure Therapy, which requires attending either weekly sessions or multiple sessions per week.

Inclusion Criteria

Report substance use at least 20 of the last 90 days

Meet DSM-5 criteria for PTSD

Are able to give informed consent

+2 more

Exclusion Criteria

I have significant memory or thinking problems.

I do not have thoughts of harming myself or others that need immediate attention.

Current unstable psychotic or manic symptoms not attributable to SUD

Participant Groups

The study is testing the effectiveness of Prolonged Exposure Therapy for PTSD when conducted in a massed format (multiple sessions weekly) compared to the standard once-a-week session schedule among veterans undergoing substance use treatment.

2Treatment groups

Experimental Treatment

Active Control

Group I: Massed PEExperimental Treatment1 Intervention

Prolonged Exposure delivered in a massed format - sessions multiple times per week

Group II: Weekly PEActive Control1 Intervention

Prolonged Exposure delivered with weekly sessions

Prolonged Exposure Therapy is already approved in United States, European Union for the following indications:

🇺🇸 Approved in United States as Prolonged Exposure Therapy for: