L-Citrulline Supplementation for Metabolic Syndrome

Recruiting in Palo Alto (17 mi)

Overseen byArturo Figueroa

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Texas Tech University

No Placebo Group

Trial Summary

What is the purpose of this trial?

The objective of this project is to provide evidence that L-Citrulline (CIT) supplementation can improve vascular function in the fasted and acute hyperglycemia conditions in middle-aged and older women with metabolic syndrome.

Research Team

Arturo Figueroa

Principal Investigator

Texas Tech University

Eligibility Criteria

This trial is for sedentary women aged 45-79 with metabolic syndrome, who don't smoke or drink heavily. They must have at least three of these: a waist size ≥88 cm, fasting glucose between 100-125 mg/dL or HbA1c between 5.7-6.4%, high blood pressure (≥130 mm Hg), high triglycerides (≥150 mg/dL), and low HDL (<50 mg/dL). BMI must be ≤39.9 kg/m2.

Inclusion Criteria

Your body mass index (BMI) is less than 39.9 kg/m2.

I have at least 3 of these: large waist, high sugar, high blood pressure, high triglycerides, or low HDL.

I am a woman aged between 45 and 79.

See 2 more

Exclusion Criteria

You weigh more than 40 kilograms for every meter of your height.

I am between 45 and 79 years old.

I have a chronic condition like heart disease or diabetes.

See 5 more

Treatment Details

Interventions

L-Citrulline Supplementation (Other)

Trial OverviewThe study tests if L-citrulline supplements can improve blood vessel function in middle-aged and older women with metabolic syndrome, especially when their blood sugar is high after eating. Participants will either receive the supplement or a placebo to compare effects.

Participant Groups

2Treatment groups

Experimental Treatment

Group I: PlaceboExperimental Treatment1 Intervention

Microcrystalline Cellulose

Group II: L-citrullineExperimental Treatment1 Intervention

L-citrulline: 10 grams/day