Mechanisms for Symptoms in Congenital Heart Disease
(PACT Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand why individuals with congenital heart disease (a condition present from birth) experience symptoms like shortness of breath and heart palpitations. Researchers are examining how these symptoms relate to changes in heart structure. The trial welcomes individuals who have undergone surgery to repair Tetralogy of Fallot or have been diagnosed with certain other heart defects, such as Ebstein's anomaly or coarctation of the aorta. It is ideal for those who have experienced significant heart valve issues, as shown in heart imaging tests. As an unphased study, this trial offers participants the chance to contribute to groundbreaking research that could enhance understanding and treatment of congenital heart disease.
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover the underlying mechanisms causing arrhythmias and reduced aerobic capacity in people with Tetralogy of Fallot and other congenital heart diseases. Unlike current treatments that mainly focus on managing symptoms or correcting structural issues through surgery, this study dives deeper into the physiological processes at play. By understanding these processes, future treatments could be developed to directly address the root causes of these complications, potentially leading to more effective and targeted interventions. This could significantly improve the quality of life for individuals affected by these conditions.
Who Is on the Research Team?
Alexander Egbe, MBBS, MPH
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Observation
Participants are monitored for right heart remodeling and aerobic capacity over the course of the study
Follow-up
Participants are monitored for safety and effectiveness after the main observation period
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
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